The Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631, Rigshospitalet, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Front Immunol. 2018 Dec 19;9:3046. doi: 10.3389/fimmu.2018.03046. eCollection 2018.
The complement is the first line of immune defense system involved in elimination of invading pathogens and dying host cells. Its activation is mainly triggered by immune complexes or pattern recognition molecules (PRMs) upon recognition against non-self or altered self-cells, such as C1q, collectins, ficolins, and properdin. Recent findings have interestingly shown that the pentraxins (C-reactive protein, CRP; serum-amyloid P component, SAP; long pentraxin 3, PTX3) are involved in complement activation and amplification via communication with complement initiation PRMs, but also complement regulation via recruitment of complement regulators, for instance C4b binding protein (C4BP) and factor H (fH). This review addresses the potential roles of the pentraxins in the complement system during infection and inflammation, and emphasizes the underlining implications of the pentraxins in the context of complement activation and regulation both under physiological and pathological conditions.
补体是参与清除入侵病原体和死亡宿主细胞的第一道免疫系统防线。其激活主要由免疫复合物或模式识别分子（PRMs）触发，这些分子在识别非自身或自身改变的细胞时，如 C1q、collectins、ficolins 和 properdin，会发生作用。最近的研究结果表明，五聚蛋白（C 反应蛋白、CRP；血清淀粉样蛋白 P 成分、SAP；长五聚蛋白 3、PTX3）通过与补体起始 PRMs 的交流参与补体激活和放大，还通过招募补体调节因子，如 C4b 结合蛋白（C4BP）和因子 H（fH），参与补体调节。本文综述了五聚蛋白在感染和炎症期间补体系统中的潜在作用，并强调了五聚蛋白在生理和病理条件下补体激活和调节中的重要意义。
