来自南极海绵衍生真菌HDN15 - 152的抗病毒和细胞毒性吲哚二萜类化合物。
Antiviral and cytotoxic indole diterpenoids from the antarctic sponge-derived fungus HDN15-152.
作者信息
Tang Bingying, Zhang Runfang, Zhang Falei, Zhu Tianjiao, Che Qian, Li Dehai, Zhang Guojian
机构信息
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
Laboratory for Marine Drugs and Bioproducts, Laoshan Laboratory, Qingdao, China.
出版信息
Nat Prod Res. 2025 Jun;39(11):3194-3201. doi: 10.1080/14786419.2024.2333050. Epub 2024 Mar 25.
One new indole diterpenoid, ascandinine T (), and three known analogues (-) were isolated from an Antarctic sponge-derived fungus HDN15-152. The structures, including absolute configurations, were established based on NMR, HRESIMS, and electronic circular dichroism (ECD) calculations. All isolated compounds were tested for antiviral and anticancer activity. Compound displayed antiviral activity against influenza A virus (IAV) of A/PR/8/34(H1N1) strain with an IC value of 39.2 M, while compound showed cytotoxicity against NCI-H446, NCI-H446/EP and L-02 cells with IC values ranging from 9.77 to 13.91 M.
从一种源自南极海绵的真菌HDN15-152中分离出一种新的吲哚二萜类化合物，阿糖宁T（），以及三种已知类似物（-）。基于核磁共振（NMR）、高分辨电喷雾电离质谱（HRESIMS）和电子圆二色光谱（ECD）计算确定了其结构，包括绝对构型。对所有分离出的化合物进行了抗病毒和抗癌活性测试。化合物对A/PR/8/34（H1N1）株甲型流感病毒（IAV）具有抗病毒活性，IC50值为39.2 μM，而化合物对NCI-H446、NCI-H446/EP和L-02细胞具有细胞毒性，IC50值在9.77至13.91 μM之间。
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