Ascandinines A-D，吲哚二萜类化合物，来自海绵来源真菌 HDN15-152。
Ascandinines A-D, Indole Diterpenoids, from the Sponge-Derived Fungus HDN15-152.
机构信息
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, P. R. China.
Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology, Qingdao 266237, P. R. China.
出版信息
J Org Chem. 2021 Feb 5;86(3):2431-2436. doi: 10.1021/acs.joc.0c02575. Epub 2021 Jan 20.
Four new indole diterpenoids, ascandinines A-D (-), were isolated from an Antarctic sponge-derived fungus HDN15-152. Their structures, including absolute configurations, were established based on NMR data, computational calculations, and biosynthetic considerations. Ascandinine A () possesses an unprecedented 2-oxabicyclo[2.2.2]octan-3-ol motif embedded in a pentacyclic ring system, while compounds - represent a rare type of indole diterpenoid featuring the 6/5/5/6/6/6/6-fused ring system. Compound displayed anti-influenza virus A (H1N1) activity with an IC value of 26 μM, while compound showed cytotoxicity against HL-60 cells with an IC value of 7.8 μM.
从南极海绵源真菌 HDN15-152 中分离得到四个新的吲哚二萜类化合物 ascandinines A-D(-)。基于 NMR 数据、计算计算和生物合成考虑，确定了它们的结构，包括绝对构型。Ascandinine A() 具有前所未有的 2-氧杂双环[2.2.2]辛烷-3-醇基序嵌入五环系统中，而化合物-代表一种罕见的吲哚二萜类化合物，具有 6/5/5/6/6/6/6-稠合环系统。化合物显示出抗流感病毒 A (H1N1) 的活性，IC 值为 26 μM，而化合物对 HL-60 细胞显示出细胞毒性，IC 值为 7.8 μM。
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