Department of Pathology and Forensic Medicine, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine;
Rom J Morphol Embryol. 2024 Jan-Mar;65(1):53-59. doi: 10.47162/RJME.65.1.07.
Obesity can cause respiratory disorders inflicted by adipose tissue accumulation and the numerous cytokines adipocytes produce. Smoking is, first of all, associated with a wide range of lung diseases characterized by diffuse changes in the lung tissue and a decrease in the respiratory volume of the lungs. The study aimed to investigate the ultrastructural changes in the lungs of sexually mature male rats under conditions of experimental obesity and smoking. The total sample of experimental animals consisted of 120 rats, divided into four groups: the control group (n=30) - conditionally healthy rats fed on a standard diet; a group of rats subjected to isolated exposure to tobacco smoke (n=30); a group of experimentally obese rats (n=30) and a group of experimentally obese rats simultaneously exposed to tobacco smoke (n=30) - feeding using a high-fat diet with exposure to a chamber with tobacco smoke. The revealed ultrastructural features of the lungs in the group of rats with experimental obesity and the group of rats with experimental obesity that were simultaneously exposed to tobacco smoke did not differ qualitatively, which indicates that pathological changes in the ultrastructure of the lung tissue developed regardless of the presence or absence of a direct damaging effect on the lung tissue of passive smoking.
肥胖可导致脂肪组织堆积和脂肪细胞产生的大量细胞因子引起的呼吸障碍。吸烟首先与多种肺部疾病有关，这些疾病的特征是肺部组织弥漫性改变和肺部呼吸量减少。本研究旨在探讨实验性肥胖和吸烟条件下性成熟雄性大鼠肺部的超微结构变化。实验动物的总样本由 120 只大鼠组成，分为四组：对照组（n=30）- 条件健康大鼠，喂食标准饮食；一组大鼠单独暴露于烟草烟雾（n=30）；一组实验性肥胖大鼠（n=30）和一组同时暴露于烟草烟雾的实验性肥胖大鼠（n=30）- 用高脂肪饮食喂养，并暴露于烟草烟雾室中。实验组肥胖大鼠和同时暴露于烟草烟雾的实验组肥胖大鼠的肺部超微结构特征在性质上没有差异，这表明无论是否存在被动吸烟对肺组织的直接损害，肺组织的超微结构病变都会发展。
