Department of Chest Diseases, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.
Clinics (Sao Paulo). 2011;66(6):1081-7. doi: 10.1590/s1807-59322011000600027.
The objective of this study was to examine the separate and combined effects of tobacco and biomass smoke exposure on pulmonary histopathology in rats.
In addition to smoking, indoor pollution in developing countries contributes to the development of respiratory diseases.
Twenty-eight adult rats were divided into four groups as follows: control group (Group I, no exposure to tobacco or biomass smoke), exposed to tobacco smoke (Group II), exposed to biomass smoke (Group III), and combined exposure to tobacco and biomass smoke (Group IV). After six months the rats in all four groups were sacrificed. Lung tissue samples were examined under light microscopy. The severity of pathological changes was scored.
Group II differed from Group I in all histopathological alterations except intraparenchymal vascular thrombosis. There was no statistically significant difference in histopathological changes between the subjects exposed exclusively to tobacco smoke (Group II) and those with combined exposure to tobacco and biomass smoke (Group IV). The histopathological changes observed in Group IV were found to be more severe than those in subjects exposed exclusively to biomass smoke (Group III).
Chronic exposure to tobacco and biomass smoke caused an increase in severity and types of lung injury.
Exposure to cigarette smoke caused serious damage to the respiratory system, particularly with concomitant exposure to biomass smoke.
本研究旨在探讨烟草和生物质烟雾暴露对大鼠肺部组织病理学的单独和联合作用。
除了吸烟，发展中国家的室内污染也促成了呼吸道疾病的发展。
将 28 只成年大鼠分为四组：对照组（I 组，未暴露于烟草或生物质烟雾）、暴露于烟草烟雾组（II 组）、暴露于生物质烟雾组（III 组）和同时暴露于烟草和生物质烟雾组（IV 组）。所有四组大鼠在六个月后被处死。检查肺组织样本的光镜检查。对病理变化的严重程度进行评分。
除了肺实质内血管血栓形成外，II 组与 I 组在所有组织病理学改变方面均有差异。仅暴露于烟草烟雾（II 组）和同时暴露于烟草和生物质烟雾（IV 组）的受试者之间的组织病理学变化无统计学差异。与单独暴露于生物质烟雾的受试者（III 组）相比，在 IV 组中观察到的组织病理学变化更为严重。
慢性暴露于烟草和生物质烟雾会导致肺部损伤的严重程度和类型增加。
暴露于香烟烟雾会对呼吸系统造成严重损害，特别是同时暴露于生物质烟雾时。
