School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, 144411, Punjab, India.
School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, 144411, Punjab, India.
Inflammopharmacology. 2024 Jun;32(3):1705-1720. doi: 10.1007/s10787-024-01445-8. Epub 2024 Mar 25.
Rheumatoid arthritis (RA) stands as an autoimmune disorder characterized by chronic joint inflammation, resulting in profound physiological alterations within the body. Affecting approximately 0.4-1.3% of the global population, this condition poses significant challenges as current therapeutic approaches primarily offer symptomatic relief, with the prospect of complete recovery remaining elusive. This review delves into the contemporary advancements in understanding the pathophysiology, diagnosis, and the therapeutic potential of herbal medicine in managing RA. Notably, early diagnosis during the initial stages emerges as the pivotal determinant for successful recovery post-treatment. Utilizing tools such as Magnetic Resonance Imaging (MRI), anti-citrullinated peptide antibody markers, and radiography proves crucial in pinpointing the diagnosis of RA with precision. Unveiling the intricate pathophysiological mechanisms of RA has paved the way for innovative therapeutic interventions, incorporating plant extracts and isolated phytoconstituents. In the realm of pharmacological therapy for RA, specific disease-modifying antirheumatic drugs have showcased commendable efficacy. However, this conventional approach is not without its drawbacks, as it is often associated with various side effects. The integration of methodological strategies, encompassing both pharmacological and plant-based herbal therapies, presents a promising avenue for achieving substantive recovery. This integrated approach not only addresses the symptoms but also strives to tackle the underlying causes of RA, fostering a more comprehensive and sustainable path towards healing.
类风湿关节炎（RA）是一种自身免疫性疾病，其特征为慢性关节炎症，导致体内发生深刻的生理变化。全球约有 0.4-1.3%的人口受到影响，尽管目前的治疗方法主要提供症状缓解，但完全康复的前景仍难以实现。本篇综述深入探讨了对类风湿关节炎的病理生理学、诊断以及草药治疗潜力的当代认识进展。值得注意的是，在治疗后成功恢复的关键是在初始阶段进行早期诊断。利用磁共振成像（MRI）、抗瓜氨酸化肽抗体标志物和 X 光等工具，精确地确定 RA 的诊断至关重要。揭示 RA 的复杂病理生理学机制为创新性治疗干预措施铺平了道路，包括植物提取物和分离的植物成分。在 RA 的药物治疗领域，特定的疾病修饰抗风湿药物已显示出良好的疗效。然而，这种传统方法并非没有缺点，因为它常常与各种副作用相关。结合药理学和植物草药疗法的方法策略，为实现实质性康复提供了有前途的途径。这种综合方法不仅针对症状，还努力解决 RA 的根本原因，为更全面和可持续的治疗途径奠定了基础。
