基于家庭的肺康复对新冠后患者运动能力的影响：一项随机对照试验。
Effect of home-based pulmonary rehabilitation on exercise capacity in post COVID-19 patients: a randomized controlled trail.
机构信息
Department of Physical Therapy for Internal Medicine, Faculty of Physical Therapy, Beni-Suef University, Beni Suef, Egypt.
Department of Chest Disease, Faculty of Medicine, Beni-Suef University, Beni Suef, Egypt.
出版信息
J Neuroeng Rehabil. 2024 Mar 25;21(1):40. doi: 10.1186/s12984-024-01340-x.
BACKGROUND
Coronavirus 2019 (COVID-19) is an epidemic condition that compromises various consequences. The goal of this study was to investigate the effect of home-based pulmonary rehabilitation on exercise capacity in patients with post COVID-19 syndrome.
METHODS
The study was designed as a randomized control trial. A total of sixty-eight patients with post COVID-19 syndrome complaining of fatigue, dyspnea, and exercise intolerance participated in this study. Their ages ranged from 40 to 70 years old. The patients were randomly classified into two equal groups. The control group received usual medical care only, whereas the rehabilitation group received a selected home-based pulmonary rehabilitation exercise program plus the same usual medical care. The Physical Fitness Index (PFI), Chalder fatigue index, SF-36 questionnaire, dyspnea scale, and six-minute walk test (6 MWT) were measured before and after 12 weeks of intervention.
RESULTS
The rehabilitation group showed a significant lower mean of Chalder fatigue (11.1 ± 0.94) and a higher mean of 6MWT (439.7 ± 25.3) and PFI (52.3 ± 10.2), in addition to a higher mean of the SF-36 Questionnaire (66.4 ± 3.7) and a significant improvement of dyspnea in the mMRC score (26.7%), grade 2, (63.3%), grade 1 (10%), and grade 0 with a p-value < 0.001 when compared to the control group.
CONCLUSION
Home-based pulmonary rehabilitation (HBPR) for patients with post COVID-19 syndrome is effective and has a potential direct influence on exercise capacity, fatigue, dyspnea, and quality of life. HBPR could be considered an adjunctive, applicable, and low-cost therapy for patients with post COVID-19 syndrome.
TRIAL REGISTRATION
The study was registered in Pan African Clinical Trial Registry as a clinical trial ID (PACTR202111640499636), November 2021.
背景
2019 年冠状病毒病（COVID-19）是一种影响多种后果的流行病症。本研究的目的是探讨基于家庭的肺康复对新冠后综合征患者运动能力的影响。
方法
本研究设计为随机对照试验。共有 68 名患有新冠后综合征、主诉疲劳、呼吸困难和运动不耐受的患者参加了这项研究。他们的年龄在 40 至 70 岁之间。患者被随机分为两组。对照组仅接受常规医疗护理，而康复组则接受选定的基于家庭的肺康复运动方案加相同的常规医疗护理。在干预 12 周前后测量了体能指数（PFI）、Chalder 疲劳指数、SF-36 问卷、呼吸困难量表和 6 分钟步行测试（6MWT）。
结果
康复组的 Chalder 疲劳评分（11.1±0.94）显著降低，6MWT（439.7±25.3）和 PFI（52.3±10.2）评分显著升高，SF-36 问卷评分（66.4±3.7）也更高，呼吸困难在 mMRC 评分中得到显著改善（26.7%，2 级；63.3%，1 级；10%，0 级），与对照组相比，p 值均<0.001。
结论
针对新冠后综合征患者的基于家庭的肺康复（HBPR）是有效的，对运动能力、疲劳、呼吸困难和生活质量有潜在的直接影响。HBPR 可以被认为是新冠后综合征患者的一种辅助、适用和低成本的治疗方法。
试验注册
本研究于 2021 年 11 月在泛非临床试验注册中心作为临床试验 ID（PACTR202111640499636）进行了注册。
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