Department of Endocrinology, The Affiliated Shunde Hospital of Jinan University, Foshan, Guangdong, 528300, P. R. China.
Department of Orthopedics Surgery, The Affiliated Shunde Hospital of Jinan University, Foshan, Guangdong, 528300, P. R. China.
Lipids Health Dis. 2024 Mar 25;23(1):88. doi: 10.1186/s12944-024-02083-3.
The accumulation of reactive oxygen species (ROS) within the bone marrow microenvironment leads to diminished osteogenic differentiation and heightened lipogenic differentiation of mesenchymal stem cells residing in the bone marrow, ultimately playing a role in the development of osteoporosis (OP). Mitigating ROS levels is a promising approach to counteracting OP. In this study, a nanozyme composed of magnesium-based zeolitic imidazolate frameworks (Mg-ZIF) was engineered to effectively scavenge ROS and alleviate OP. The results of this study indicate that Mg-ZIF exhibits significant potential in scavenging ROS and effectively promoting osteogenic differentiation of bone mesenchymal stem cells (BMSCs). Additionally, Mg-ZIF was found to inhibit the differentiation of BMSCs into adipose cells. In vivo experiments further confirmed the ability of Mg-ZIF to mitigate OP by reducing ROS levels. Mechanistically, Mg-ZIF enhances the differentiation of BMSCs into osteoblasts by upregulating lipid metabolic pathways through ROS scavenging. The results indicate that Mg-ZIF has potential as an effective therapeutic approach for the treatment of osteoporosis.
骨髓微环境中活性氧（ROS）的积累导致骨髓中存在的间充质干细胞的成骨分化减少和脂肪生成分化增加，最终在骨质疏松症（OP）的发展中发挥作用。减轻 ROS 水平是对抗 OP 的一种有前途的方法。在这项研究中，设计了一种由镁基沸石咪唑酯骨架（Mg-ZIF）组成的纳米酶，以有效清除 ROS 并缓解 OP。研究结果表明，Mg-ZIF 在清除 ROS 和有效促进骨髓间充质干细胞（BMSCs）的成骨分化方面具有显著的潜力。此外，还发现 Mg-ZIF 能够通过抑制 BMSCs 向脂肪细胞分化来抑制 BMSCs 向脂肪细胞分化。体内实验进一步证实了 Mg-ZIF 通过降低 ROS 水平减轻 OP 的能力。从机制上讲，Mg-ZIF 通过清除 ROS 增强了 BMSCs 向成骨细胞的分化，上调了脂质代谢途径。结果表明，Mg-ZIF 具有作为治疗骨质疏松症的有效治疗方法的潜力。
