Department of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China.
J Nanobiotechnology. 2024 Sep 16;22(1):569. doi: 10.1186/s12951-024-02844-3.
Nanozymes, a category of nanomaterials with enzyme-like activity, have garnered growing interest in various biomedical contexts. Notably, nanozymes that are capable of regulating reactive oxygen species levels by emulating antioxidant or prooxidant enzymes within cells hold significant therapeutic potential for a range of disorders. Herein, we overview the catalytic mechanisms of four exemplary nanozymes within the orthopedic domain. Subsequently, we emphasize recent groundbreaking advancements in nanozyme applications in orthopaedics, encompassing osteoarthritis, osteoporosis, intervertebral disc degeneration, bone defects, spinal cord injury, gout, rheumatoid arthritis, osteosarcoma and bone infection. Furthermore, we discuss the emerging area's future prospects and several noteworthy challenges in biomedical application. This review not only fosters the ongoing development of nanozyme research but also fosters the emergence of more potent nanozymes for the treatment of orthopaedical diseases in the future.
纳米酶，一类具有类似酶活性的纳米材料，在各种生物医学领域引起了越来越多的关注。特别是能够模拟细胞内抗氧化酶或促氧化剂酶来调节活性氧水平的纳米酶，为一系列疾病提供了重要的治疗潜力。本文综述了骨科领域四种典型纳米酶的催化机制。随后，我们强调了纳米酶在骨科应用中的最新突破性进展，涵盖了骨关节炎、骨质疏松症、椎间盘退变、骨缺损、脊髓损伤、痛风、类风湿性关节炎、骨肉瘤和骨感染。此外，我们还讨论了这一新兴领域在生物医学应用中的未来前景和几个值得注意的挑战。本综述不仅促进了纳米酶研究的不断发展，也为未来治疗骨科疾病的更有效纳米酶的出现奠定了基础。
