Brunelin Jerome, Neige Cécilia, Eche Julien, Galvao Filipe, Bation Rémy, Mondino Marine
Centre Hospitalier Le Vinatier, Bron, France.
Université Claude Bernard Lyon 1, CNRS, INSERM, Centre de Recherche en Neurosciences de Lyon CRNL U1028 UMR5292, PSYR2, Bron, France.
Front Hum Neurosci. 2024 Mar 11;17:1327811. doi: 10.3389/fnhum.2023.1327811. eCollection 2023.
Hoarding disorder is an under-recognized condition characterized by the excessive acquisition of possessions and difficulty in disposing of them, which can have dramatic consequences. As hoarding disorder is difficult to treat and associated with high levels of disability in all areas of functioning, there appears to be a critical need to develop novel, tailored therapeutic strategies. Non-invasive brain stimulation techniques hold promise as potential therapeutic interventions for various psychiatric conditions and as a tool to modulate impulsivity when applied over the dorsolateral prefrontal cortex (DLPFC). Therefore, we hypothesized that delivering accelerated cathodal high-definition direct transcranial stimulation (HD-tDCS) over the right DLPFC could be a suitable approach to alleviate symptoms in patients with hoarding disorder. In a case report, we observed beneficial clinical effects on acquisition and depressive symptoms after 15 sessions of three daily 20-min sessions. Accelerated cathodal HD-tDCS over the right DLPFC appears to be a safe and appropriate intervention for patients with hoarding disorder. However, randomized, sham-controlled trials are needed to further validate these encouraging findings.
囤积障碍是一种未得到充分认识的病症，其特征为过度获取物品且难以丢弃这些物品，这可能会产生严重后果。由于囤积障碍难以治疗且在各个功能领域都与高度残疾相关，因此迫切需要开发新颖、量身定制的治疗策略。非侵入性脑刺激技术有望成为各种精神疾病的潜在治疗干预手段，并且在应用于背外侧前额叶皮层（DLPFC）时可作为调节冲动性的工具。因此，我们假设在右侧DLPFC上进行加速阴极高清直接经颅刺激（HD-tDCS）可能是缓解囤积障碍患者症状的合适方法。在一份病例报告中，我们观察到在每天进行3次、每次20分钟、共15次治疗后，患者在物品获取和抑郁症状方面出现了有益的临床效果。对右侧DLPFC进行加速阴极HD-tDCS似乎是囤积障碍患者的一种安全且合适的干预措施。然而，需要进行随机、假对照试验来进一步验证这些令人鼓舞的发现。
