一碳归一碳：甲醛是连接一碳代谢与表观遗传甲基化的一碳信号。
One Carbon to Rule Them All: Formaldehyde is a One-Carbon Signal Connecting One-Carbon Metabolism and Epigenetic Methylation.
出版信息
ACS Chem Biol. 2024 Apr 19;19(4):798-801. doi: 10.1021/acschembio.4c00106. Epub 2024 Mar 26.
Abstract
Formaldehyde is commonly thought of as an environmental toxin or laboratory fixation reagent, but there is a growing appreciation for its broader physiological contributions as a naturally generated one-carbon metabolite across all kingdoms of life. In this In Focus article, we summarize emerging advances in the field that show how formaldehyde plays diverse roles as a one-carbon signal in DNA damage, one-carbon metabolism, and epigenetic regulation.
摘要
甲醛通常被认为是一种环境毒素或实验室固定试剂，但人们越来越认识到它作为一种在所有生命领域中自然产生的一碳代谢物的更广泛的生理贡献。在这篇特写文章中，我们总结了该领域的新进展，这些进展表明甲醛如何作为 DNA 损伤、一碳代谢和表观遗传调控中的一碳信号发挥多种作用。
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