Olas Beata
Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland.
Front Pharmacol. 2024 Mar 12;15:1366076. doi: 10.3389/fphar.2024.1366076. eCollection 2024.
Hyperactivation of blood platelets, one of the causes of heart attack, and other cardiovascular diseases (CVDs), is influenced by various dietary components, including phenolic compounds from vegetables, fruits, teas, wines, cocoa and its products, including chocolate. The present paper sheds new light on the effect of cocoa and its products, especially dark chocolate, on the number and function of blood platelets, and the anti-platelet activity of their constituent phenolic compounds. A review was performed of papers identified in various electronic databases, including PubMed, Science Direct, Scopus, Web of Knowledge, and Google Scholar, with the aim of determining whether their anti-platelet activity may serve as part of a sweet strategy in countering CVDs. Various studies demonstrate that cocoa consumption, especially in the form of dark chocolate, with a high flavanol concentration, has anti-platelet activity and may play a significant role in cardioprotection; they also note that cocoa consumption may be a good strategy in diminishing cardiovascular risk, including hyperactivation of blood platelets.
血小板过度活化是心脏病发作及其他心血管疾病(CVD)的病因之一,它受多种饮食成分的影响,包括蔬菜、水果、茶、葡萄酒、可可及其制品(包括巧克力)中的酚类化合物。本文揭示了可可及其制品,尤其是黑巧克力,对血小板数量和功能的影响,以及其所含酚类化合物的抗血小板活性。对在多个电子数据库(包括PubMed、Science Direct、Scopus、Web of Knowledge和Google Scholar)中检索到的论文进行了综述,目的是确定它们的抗血小板活性是否可作为对抗心血管疾病的甜蜜策略的一部分。各种研究表明,食用可可,尤其是高黄烷醇浓度的黑巧克力,具有抗血小板活性,可能在心脏保护中发挥重要作用;研究还指出,食用可可可能是降低心血管风险(包括血小板过度活化)的良好策略。