Department of Endocrinology and Metabolism Peking University People's Hospital Peking University Diabetes Center Beijing China.
China-Japan Friendship Hospital Beijing China.
J Diabetes Investig. 2014 May 4;5(3):286-9. doi: 10.1111/jdi.12145. Epub 2013 Nov 15.
A genome-wide association study in the Chinese Han population has identified several novel genetic variants of the serine racemase (SRR) gene in type 2 diabetes. Our purpose was to systematically evaluate the contribution of SRR variants in the Chinese Han population. rs391300 and rs4523957 in SRR were genotyped respectively in the two independent populations. A meta-analysis was used to estimate the effects of SRR in 21,305 Chinese Han individuals. Associations between single-nucleotide polymorphisms and diabetes-related phenotypes were analyzed among 2,615 newly diagnosed type 2 diabetes patients and 5,029 controls. Neither rs391300 nor rs4523957 were associated with type 2 diabetes in populations. Furthermore, meta-analysis did not confirm an association between type 2 diabetes and SRR. In the controls, rs391300-A and rs4523957-G were associated with higher 30-min plasma glucose in an oral glucose tolerance test. The present study did not confirm that SRR was associated with type 2 diabetes.
一项全基因组关联研究在中国汉族人群中鉴定出了几种新型丝氨酸消旋酶（SRR）基因的遗传变异与 2 型糖尿病有关。我们的目的是系统地评估 SRR 变异在中国汉族人群中的作用。分别在两个独立的人群中对 SRR 的 rs391300 和 rs4523957 进行了基因分型。采用荟萃分析来估计 21305 名中国汉族个体中 SRR 的作用。在 2615 名新诊断的 2 型糖尿病患者和 5029 名对照中分析了单核苷酸多态性与糖尿病相关表型之间的关系。rs391300 或 rs4523957 在人群中均与 2 型糖尿病无关。此外，荟萃分析也未证实 SRR 与 2 型糖尿病之间存在关联。在对照组中，口服葡萄糖耐量试验中 rs391300-A 和 rs4523957-G 与较高的 30 分钟血浆葡萄糖水平相关。本研究并未证实 SRR 与 2 型糖尿病有关。
