监测接受药物辅助治疗患者的丁丙诺啡使用情况。
Monitoring buprenorphine in patients on medication-assisted treatment.
机构信息
Precision Diagnostics LLC, San Diego, California. ORCID: https://orcid.org/0000-0003-3748-9703.
Precision Diagnostics LLC, San Diego, California.
出版信息
J Opioid Manag. 2024 Jan-Feb;20(1):15-20. doi: 10.5055/jom.0844.
BACKGROUND
Buprenorphine is used for medication-assisted treatment of opioid dependence.
PURPOSE
Monitoring of medication adherence involves testing of urine or oral fluid for the drug or its metabolite.
METHODS
Quantitative results using liquid chromatography tandem mass spectrometer testing defined the excretion pattern of the drug and its metabolites.
RESULTS
Frequency distribution curves of buprenorphine and norbuprenorphine describe the expected drug concentrations of patients on this medication.
CONCLUSION
Urine and oral fluid drug testing can be used to monitor adherence in this population.
背景
丁丙诺啡用于阿片类药物依赖的药物辅助治疗。
目的
药物依从性监测包括检测尿液或口腔液中的药物或其代谢物。
方法
使用液相色谱串联质谱检测法定量结果定义了药物及其代谢物的排泄模式。
结果
丁丙诺啡和去甲丁丙诺啡的频率分布曲线描述了接受这种药物治疗的患者的预期药物浓度。
结论
尿液和口腔液药物检测可用于监测该人群的依从性。
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