Neuroscience Axis, CRCHUQ, Université Laval, Québec-city, G1V 4G2, Canada.
Department of Biochemistry, Microbiology and Bio-Informatics, Neuroscience Axis, CHU de Québec Research Center, Laval University, Québec, PQ, Canada.
Curr Opin Neurobiol. 2019 Feb;54:98-103. doi: 10.1016/j.conb.2018.09.006. Epub 2018 Oct 12.
Understanding of how intracellular calcium (Ca) signals regulate the efficacy of transmission at excitatory and inhibitory synapses in the central nervous system (CNS) has been a focus of intense investigation. This review discusses recent findings on how Ca signals are integrated in dendrites of inhibitory interneurons to regulate their synapses. In particular, Ca signaling through intracellular Ca release plays an essential role in synaptic signal transduction and experience-dependent plasticity in dendrites of interneurons. Understanding the alternative pathways of Ca signaling in the absence of canonical voltage-gated Ca mechanisms is beginning to shed light on how their regulation can contribute to interneuron function and dysfunction in disease.
理解细胞内钙离子（Ca）信号如何调节中枢神经系统（CNS）中兴奋性和抑制性突触的传递效率一直是研究的重点。本文讨论了最近关于 Ca 信号如何在抑制性中间神经元的树突中整合以调节其突触的发现。特别是，通过细胞内 Ca 释放的 Ca 信号在突触信号转导和神经元树突中的经验依赖性可塑性中发挥着重要作用。理解在没有典型电压门控 Ca 机制的情况下 Ca 信号的替代途径，开始揭示其调节如何有助于疾病中中间神经元的功能和功能障碍。
