Xu Sumei, Zhang Yating, Huang Qi, Xie Yiwen, Tong Xiaojuan, Liu Haoge
The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China.
Zhejiang Chinese Medical University, Hangzhou, China.
Medicine (Baltimore). 2024 Dec 6;103(49):e40835. doi: 10.1097/MD.0000000000040835.
Autophagy is a cellular process in which damaged organelles or unnecessary proteins are encapsulated into double-membrane structures and transported to lysosomes for degradation. Autophagy plays a crucial role in various liver diseases, including nonalcoholic fatty liver disease. This study aims to elucidate the role of autophagy in nonalcoholic fatty liver disease through bibliometric analysis.
Literature was retrieved from Web of Science CoreCollection database, and the search time was from January 01, 2004 to December 31, 2023. Data retrieval was performed using the Bibliometrix package in R software. VOSviewer and CiteSpace were utilized to visualize the research hotspots and trends related to the effect of autophagy on nonalcoholic fatty liver disease.
A total of 966 papers were obtained, published in 343 journals from 1385 institutions across 57 countries. The journals with the most publications were the "International Journal of Molecular Sciences" and "Scientific Reports." China had the highest number of published papers. The most productive authors were Yen Paul M and Jung Tae Woo, while Singh R was the most frequently co-cited author. Emerging research hotspots were associated with keywords such as insulin resistance, ferroptosis, endoplasmic reticulum stress, and mitochondrial function.
Research on autophagy in nonalcoholic fatty liver disease is still in its early stages, with a growing body of literature. This study is the first to provide a comprehensive bibliometric analysis, synthesizing research trends and advancements. It identifies current development trends, global cooperation models, foundational knowledge, research hotspots, and emerging frontiers in the field.
自噬是一种细胞过程，其中受损的细胞器或不必要的蛋白质被包裹在双膜结构中，并被运输到溶酶体进行降解。自噬在包括非酒精性脂肪性肝病在内的各种肝脏疾病中起着至关重要的作用。本研究旨在通过文献计量分析阐明自噬在非酒精性脂肪性肝病中的作用。
从Web of Science核心合集数据库中检索文献，检索时间为2004年1月1日至2023年12月31日。使用R软件中的Bibliometrix软件包进行数据检索。利用VOSviewer和CiteSpace可视化与自噬对非酒精性脂肪性肝病影响相关的研究热点和趋势。
共获得966篇论文，发表在来自57个国家1385个机构的343种期刊上。发表论文最多的期刊是《国际分子科学杂志》和《科学报告》。中国发表的论文数量最多。发文量最高的作者是Yen Paul M和Jung Tae Woo，而Singh R是被引用次数最多的共同作者。新兴研究热点与胰岛素抵抗、铁死亡、内质网应激和线粒体功能等关键词相关。
非酒精性脂肪性肝病中自噬的研究仍处于早期阶段，文献数量不断增加。本研究首次提供了全面的文献计量分析，综合了研究趋势和进展。它确定了该领域当前的发展趋势、全球合作模式、基础知识、研究热点和新兴前沿。
