Olajiga Olayinka M, Jameson Samuel B, Carter Brendan H, Wesson Dawn M, Mitzel Dana, Londono-Renteria Berlin
Department of Tropical Medicine and Infectious Disease, Tulane University, New Orleans, LA 70112, USA.
Animal Diseases Research Unit, National Bio- and Agro-Defense Facility, United States Department of Agriculture, Agricultural Research Service, Manhattan, KS 66506, USA.
Biology (Basel). 2024 Mar 15;13(3):188. doi: 10.3390/biology13030188.
This review examines the advancements and methodologies of artificial feeding systems for the study of vector-borne diseases, offering a critical assessment of their development, advantages, and limitations relative to traditional live host models. It underscores the ethical considerations and practical benefits of such systems, including minimizing the use of live animals and enhancing experimental consistency. Various artificial feeding techniques are detailed, including membrane feeding, capillary feeding, and the utilization of engineered biocompatible materials, with their respective applications, efficacy, and the challenges encountered with their use also being outlined. This review also forecasts the integration of cutting-edge technologies like biomimicry, microfluidics, nanotechnology, and artificial intelligence to refine and expand the capabilities of artificial feeding systems. These innovations aim to more accurately simulate natural feeding conditions, thereby improving the reliability of studies on the transmission dynamics of vector-borne diseases. This comprehensive review serves as a foundational reference for researchers in the field, proposing a forward-looking perspective on the potential of artificial feeding systems to revolutionize vector-borne disease research.
本综述探讨了用于研究媒介传播疾病的人工喂养系统的进展和方法，对其相对于传统活体宿主模型的发展、优势和局限性进行了批判性评估。它强调了此类系统的伦理考量和实际益处，包括尽量减少活体动物的使用并提高实验的一致性。详细介绍了各种人工喂养技术，包括膜喂养、毛细管喂养以及工程生物相容性材料的应用，还概述了它们各自的应用、功效以及使用过程中遇到的挑战。本综述还预测了仿生学、微流体技术、纳米技术和人工智能等前沿技术的整合，以改进和扩展人工喂养系统的功能。这些创新旨在更准确地模拟自然喂养条件，从而提高媒介传播疾病传播动力学研究的可靠性。这篇全面的综述为该领域的研究人员提供了基础参考，对人工喂养系统在革新媒介传播疾病研究方面的潜力提出了前瞻性观点。
