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秘鲁中重度新冠肺炎住院患者社区获得性感染的识别与临床特征

Identification and Clinical Characteristics of Community-Acquired in Patients Hospitalized for Moderate or Severe COVID-19 in Peru.

作者信息

Silva-Caso Wilmer, Pérez-Lazo Giancarlo, Aguilar-Luis Miguel Angel, Morales-Moreno Adriana, Ballena-López José, Soto-Febres Fernando, Martins-Luna Johanna, Del Valle Luis J, Kym Sungmin, Aguilar-Luis Deysi, Denegri-Hinostroza Dayana, Del Valle-Mendoza Juana

机构信息

School of Medicine, Research Center of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru.

Division of Infectious Diseases, Guillermo Almenara Irigoyen National Hospital-EsSalud, Lima 15033, Peru.

出版信息

Antibiotics (Basel). 2024 Mar 16;13(3):266. doi: 10.3390/antibiotics13030266.

Abstract

has been described as a cause of serious community-acquired infections in tropical countries. Currently, its implications when simultaneously identified with other pathogens are not yet adequately understood. A descriptive study was conducted on hospitalized patients with a diagnosis of moderate/severe SARS-CoV-2-induced pneumonia confirmed via real-time RT-PCR. Patients aged > 18 years who were admitted to a specialized COVID-19 treatment center in Peru were selected for enrollment. was detected via the PCR amplification of the gene obtained from nasopharyngeal swabs within 48 h of hospitalization. A total of 295 patients with COVID-19 who met the study inclusion criteria were enrolled. was simultaneously identified in 40/295 (13.5%) of COVID-19-hospitalized patients. Demographic data and comorbidities were comparable in both -positive and -negative subgroups. However, patients identified as being infected with were more likely to have received outpatient antibiotics prior to hospitalization, had a higher requirement for high-flow nasal cannula and a higher subjective incidence of fatigue, and were more likely to develop -induced pneumonia during hospitalization. Conclusions: The group in which SARS-CoV-2 and were simultaneously identified had a higher proportion of fatigue, a higher frequency of requiring a high-flow cannula, and a higher proportion of superinfection with the same microorganism during hospitalization.

摘要

在热带国家,它已被描述为严重社区获得性感染的一个病因。目前,当它与其他病原体同时被识别时,其影响尚未得到充分理解。对通过实时逆转录聚合酶链反应确诊为中度/重度SARS-CoV-2诱导性肺炎的住院患者进行了一项描述性研究。选择年龄大于18岁且入住秘鲁一家专门的COVID-19治疗中心的患者进行入组。在住院48小时内,通过对从鼻咽拭子中获得的 基因进行聚合酶链反应扩增来检测 。共有295名符合研究纳入标准的COVID-19患者入组。在40/295(13.5%)的COVID-19住院患者中同时检测到 。在 阳性和 阴性亚组中,人口统计学数据和合并症具有可比性。然而,被确定感染 的患者在住院前更有可能接受过门诊抗生素治疗,对高流量鼻导管的需求更高,主观疲劳发生率更高,并且在住院期间更有可能发生 诱导的肺炎。结论:同时检测到SARS-CoV-2和 的组在住院期间疲劳比例更高,需要高流量导管的频率更高,同一微生物的重叠感染比例更高。

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