Silva-Caso Wilmer, Pérez-Lazo Giancarlo, Aguilar-Luis Miguel Angel, Morales-Moreno Adriana, Ballena-López José, Soto-Febres Fernando, Martins-Luna Johanna, Del Valle Luis J, Kym Sungmin, Aguilar-Luis Deysi, Denegri-Hinostroza Dayana, Del Valle-Mendoza Juana
School of Medicine, Research Center of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru.
Division of Infectious Diseases, Guillermo Almenara Irigoyen National Hospital-EsSalud, Lima 15033, Peru.
Antibiotics (Basel). 2024 Mar 16;13(3):266. doi: 10.3390/antibiotics13030266.
has been described as a cause of serious community-acquired infections in tropical countries. Currently, its implications when simultaneously identified with other pathogens are not yet adequately understood. A descriptive study was conducted on hospitalized patients with a diagnosis of moderate/severe SARS-CoV-2-induced pneumonia confirmed via real-time RT-PCR. Patients aged > 18 years who were admitted to a specialized COVID-19 treatment center in Peru were selected for enrollment. was detected via the PCR amplification of the gene obtained from nasopharyngeal swabs within 48 h of hospitalization. A total of 295 patients with COVID-19 who met the study inclusion criteria were enrolled. was simultaneously identified in 40/295 (13.5%) of COVID-19-hospitalized patients. Demographic data and comorbidities were comparable in both -positive and -negative subgroups. However, patients identified as being infected with were more likely to have received outpatient antibiotics prior to hospitalization, had a higher requirement for high-flow nasal cannula and a higher subjective incidence of fatigue, and were more likely to develop -induced pneumonia during hospitalization. Conclusions: The group in which SARS-CoV-2 and were simultaneously identified had a higher proportion of fatigue, a higher frequency of requiring a high-flow cannula, and a higher proportion of superinfection with the same microorganism during hospitalization.
在热带国家,它已被描述为严重社区获得性感染的一个病因。目前,当它与其他病原体同时被识别时,其影响尚未得到充分理解。对通过实时逆转录聚合酶链反应确诊为中度/重度SARS-CoV-2诱导性肺炎的住院患者进行了一项描述性研究。选择年龄大于18岁且入住秘鲁一家专门的COVID-19治疗中心的患者进行入组。在住院48小时内,通过对从鼻咽拭子中获得的 基因进行聚合酶链反应扩增来检测 。共有295名符合研究纳入标准的COVID-19患者入组。在40/295(13.5%)的COVID-19住院患者中同时检测到 。在 阳性和 阴性亚组中,人口统计学数据和合并症具有可比性。然而,被确定感染 的患者在住院前更有可能接受过门诊抗生素治疗,对高流量鼻导管的需求更高,主观疲劳发生率更高,并且在住院期间更有可能发生 诱导的肺炎。结论:同时检测到SARS-CoV-2和 的组在住院期间疲劳比例更高,需要高流量导管的频率更高,同一微生物的重叠感染比例更高。