Bretto Elisabetta, Frara Simone, Armandi Angelo, Caviglia Gian Paolo, Saracco Giorgio Maria, Bugianesi Elisabetta, Pitoni Demis, Ribaldone Davide Giuseppe
Department of Medical Sciences, University of Turin, 10126 Turin, Italy.
Unit of Gastroenterology, Città della Salute e della Scienza di Torino-Molinette Hospital, 10126 Turin, Italy.
Antibiotics (Basel). 2024 Mar 17;13(3):267. doi: 10.3390/antibiotics13030267.
() infection is a prominent entity within human infectious diseases which cause chronic gastritis, peptic ulcers, gastric malignancies, and extragastric disorders. Its persistent colonization can lead to a systemic inflammatory cascade, potentially instigating autoimmune responses and contributing to the pathogenesis of autoimmune diseases. While the specific etiopathogenesis of inflammatory bowel diseases (IBDs) is still unknown, it is widely recognized that immunological, genetic, and environmental factors are implicated. Various bacterial and viral pathogens have been implicated in the pathogenesis of IBDs. Numerous studies suggest a correlation between infection and IBDs. While subject to debate, this link suggests that the bacterium's presence somehow impacts the progression of IBDs by modifying the diversity of the gut microbiota, consequently altering local chemical profiles and disrupting the pattern of gut immune response. However, epidemiological evidence indicates a protective role of infection against the onset of autoimmune diseases. Additionally, laboratory findings demonstrate 's capacity to promote immune tolerance and restrict inflammatory reactions. The aim of this review is to elucidate the proposed mechanisms and confounding factors that underlie the potential association between infection and IBDs.
（）感染是人类传染病中的一个突出病种，可导致慢性胃炎、消化性溃疡、胃癌及胃外疾病。其持续定植可引发全身炎症级联反应，可能引发自身免疫反应并促进自身免疫性疾病的发病机制。虽然炎症性肠病（IBD）的具体病因仍不清楚，但人们普遍认识到免疫、遗传和环境因素与之有关。各种细菌和病毒病原体已被认为与IBD的发病机制有关。大量研究表明（）感染与IBD之间存在关联。尽管存在争议，但这种联系表明该细菌的存在以某种方式通过改变肠道微生物群的多样性影响IBD的进展，从而改变局部化学特征并破坏肠道免疫反应模式。然而，流行病学证据表明（）感染对自身免疫性疾病的发病具有保护作用。此外，实验室研究结果表明（）具有促进免疫耐受和限制炎症反应的能力。本综述的目的是阐明（）感染与IBD之间潜在关联的提出机制和混杂因素。
