儿童幽门螺杆菌感染与炎症性肠病的关系：系统评价与荟萃分析。

The association between Helicobacter pylori infection and inflammatory bowel disease in children: A systematic review with meta-analysis.

机构信息

Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

出版信息

Medicine (Baltimore). 2023 Sep 8;102(36):e34882. doi: 10.1097/MD.0000000000034882.

DOI:10.1097/MD.0000000000034882

PMID:37682136

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10489354/

Abstract

BACKGROUND

Available literature has reported the association of Helicobacter pylori (H pylori) infection with inflammatory bowel disease (IBD) in adults. However, only a few studies have addressed the disease in children.

AIM

To ascertain the correlation of H pylori infection with IBD among children.

METHODS

The aim of this systematic review and meta-analysis is to assess the association between H pylori infection and IBD in children. We searched databases including Cochrane, EMBASE, Google Scholar, PubMed, Medline, and Web of Science to select relevant studies. Ultimately, based on predetermined inclusion criteria, we included 6 studies that met the requirements. Review Manager and Stata software were used to extract and analyze the data from the relevant studies. In the methods, we employed both qualitative and quantitative approaches for comprehensive analysis. Qualitative analysis involved describing study designs, sample characteristics, and results, while quantitative analysis involved statistical tests such as calculating pooled risk ratios and 95% confidence intervals to evaluate the association between H pylori infection and IBD in children. Lastly, by combining the results of the individual studies, our objective is to provide a comprehensive understanding of the relationship between H pylori infection and IBD in children.

RESULTS

In totality, we involved 2236 participants that were recruited in 6 studies. We detected no significant difference in H pylori prevalence (9.8% vs 12.7%, P = .12) by comparing the children IBD group to controls. Among the IBD children, we estimated odds ratio (OR) of H pylori infection to 0.62 [(95% confidence interval (CI) of 0.34-1.12)]. In children suffering from ulcerative colitis (UC) and Crohn disease (CD), the H pylori infection rates were higher than in those with IBD-unclassified (IBDU).When analyzed stratified by disease of study design, In CD group [OR = 1.42, 95% CI: 0.72-2.80)] (I2 = 0%, P = .64). but no significant difference in CD group.

CONCLUSIONS

No correlation was found between H pylori infection and the occurrence of IBD in children.

摘要

背景

现有文献报道了幽门螺杆菌（H pylori）感染与成人炎症性肠病（IBD）之间的关联。然而，仅有少数研究涉及儿童中的这种疾病。

目的

确定 H pylori 感染与儿童 IBD 之间的相关性。

方法

本系统评价和荟萃分析的目的是评估 H pylori 感染与儿童 IBD 之间的关联。我们检索了 Cochrane、EMBASE、Google Scholar、PubMed、Medline 和 Web of Science 等数据库，以选择相关研究。最终，根据预先确定的纳入标准，我们纳入了符合要求的 6 项研究。使用 Review Manager 和 Stata 软件提取和分析相关研究的数据。在方法部分，我们采用定性和定量方法进行综合分析。定性分析包括描述研究设计、样本特征和结果，而定量分析包括计算汇总风险比和 95%置信区间等统计检验，以评估 H pylori 感染与儿童 IBD 之间的关联。最后，通过合并个体研究的结果，我们的目标是全面了解 H pylori 感染与儿童 IBD 之间的关系。

结果

总共纳入了 6 项研究的 2236 名参与者。我们发现，将 IBD 患儿组与对照组进行比较时，H pylori 患病率没有显著差异（9.8%对 12.7%，P =.12）。在 IBD 患儿中，我们估计 H pylori 感染的优势比（OR）为 0.62（95%置信区间（CI）为 0.34-1.12））。在溃疡性结肠炎（UC）和克罗恩病（CD）患儿中，H pylori 感染率高于 IBD 未分类（IBDU）患儿。当按研究设计的疾病进行分层分析时，在 CD 组[OR = 1.42，95%CI：0.72-2.80)]（I2 = 0%，P =.64）]。但在 CD 组中无显著差异。