Wu Kevin Y, Tabari Adrian, Mazerolle Éric, Tran Simon D
Division of Ophthalmology, Department of Surgery, University of Sherbrooke, Sherbrooke, QC J1G 2E8, Canada.
Southern Medical Program, Faculty of Medicine, University of British Columbia, Kelowna, BC V1V 1V7, Canada.
Biomimetics (Basel). 2024 Feb 27;9(3):145. doi: 10.3390/biomimetics9030145.
In the forefront of ophthalmic innovation, biomimetic 3D printing and bioprinting technologies are redefining patient-specific therapeutic strategies. This critical review systematically evaluates their application spectrum, spanning oculoplastic reconstruction, retinal tissue engineering, corneal transplantation, and targeted glaucoma treatments. It highlights the intricacies of these technologies, including the fundamental principles, advanced materials, and bioinks that facilitate the replication of ocular tissue architecture. The synthesis of primary studies from 2014 to 2023 provides a rigorous analysis of their evolution and current clinical implications. This review is unique in its holistic approach, juxtaposing the scientific underpinnings with clinical realities, thereby delineating the advantages over conventional modalities, and identifying translational barriers. It elucidates persistent knowledge deficits and outlines future research directions. It ultimately accentuates the imperative for multidisciplinary collaboration to enhance the clinical integration of these biotechnologies, culminating in a paradigm shift towards individualized ophthalmic care.
在眼科创新的前沿，仿生3D打印和生物打印技术正在重新定义针对患者的治疗策略。这篇批判性综述系统地评估了它们的应用范围，涵盖眼部整形重建、视网膜组织工程、角膜移植和靶向青光眼治疗。它突出了这些技术的复杂性，包括促进眼部组织结构复制的基本原理、先进材料和生物墨水。对2014年至2023年的初步研究进行综合分析，对它们的发展演变和当前临床意义进行了严谨剖析。这篇综述的独特之处在于其全面的方法，将科学基础与临床实际相结合，从而阐明相对于传统方式的优势，并确定转化障碍。它阐明了持续存在的知识空白，并概述了未来的研究方向。最终强调了多学科合作对于加强这些生物技术临床整合的必要性，最终促成向个性化眼科护理的范式转变。
