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女性生殖道小儿血管瘤:文献综述

Pediatric Hemangiomas in the Female Genital Tract: A Literature Review.

作者信息

Merlino Lucia, Volpicelli Agnese Immacolata, Anglana Franco, D'Ovidio Giulia, Dominoni Mattia, Pasquali Marianna Francesca, Gardella Barbara, Inghirami Paolo, Lippa Pietro, Senatori Roberto

机构信息

Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 00161 Rome, Italy.

Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00161 Rome, Italy.

出版信息

Diseases. 2024 Feb 28;12(3):48. doi: 10.3390/diseases12030048.

DOI:10.3390/diseases12030048
PMID:38534972
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10969121/
Abstract

BACKGROUND

Hemangiomas are aberrant proliferations of blood vessels and the most frequent benign pediatric soft tissue tumors. Although they are common, genital localization is rare. This study aimed to assist doctors in the diagnosis, management, and treatment of pediatric vulvovaginal hemangiomas by conducting a review of the literature.

METHODS

We conducted a literature review including papers published between August 2009 and May 2023.

RESULTS

While most hemangiomas are usually indolent and resolve with time, in some cases, especially cervicovaginal and uterine ones, they might present with severe symptoms like heavy bleeding and need further instrumental investigation for diagnosis, like CT or MRI. As for the treatment, many options are available, with medical therapy or expectant management being the first choice.

CONCLUSIONS

Vulvovaginal pediatric hemangiomas are rare and require more research on how to detect and manage these lesions, especially the symptomatic and the psychologically impacting ones. For the time being, treatment should be personalized based on the patient's situation and clinician's expertise.

摘要

背景

血管瘤是血管的异常增殖,是儿科最常见的良性软组织肿瘤。虽然它们很常见,但发生于生殖器部位的情况却很罕见。本研究旨在通过文献综述,帮助医生诊断、管理和治疗小儿外阴阴道血管瘤。

方法

我们进行了一项文献综述,纳入了2009年8月至2023年5月发表的论文。

结果

虽然大多数血管瘤通常进展缓慢并会随时间消退,但在某些情况下,尤其是宫颈阴道和子宫部位的血管瘤,可能会出现严重症状,如大量出血,需要进一步借助CT或MRI等仪器检查来进行诊断。至于治疗,有多种选择,药物治疗或观察等待是首选。

结论

小儿外阴阴道血管瘤较为罕见,需要更多关于如何检测和管理这些病变的研究,尤其是有症状的以及对心理有影响的病变。目前,应根据患者情况和临床医生的专业知识进行个性化治疗。

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引用本文的文献

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Vulvar Hemangioma: A Review.外阴血管瘤:综述
Diagnostics (Basel). 2025 May 16;15(10):1270. doi: 10.3390/diagnostics15101270.

本文引用的文献

1
Vulvar tumor in an infant.
Pediatr Dermatol. 2022 Sep;39(5):E3-E4. doi: 10.1111/pde.15010.
2
Infantile/Capillary Hemangioma of the Uterine Corpus: A Rare Cause of Abnormal Genital Bleeding.子宫体婴儿/毛细血管型血管瘤:异常生殖器出血的罕见原因。
J Pediatr Adolesc Gynecol. 2022 Oct;35(5):597-600. doi: 10.1016/j.jpag.2022.02.001. Epub 2022 Mar 15.
3
Infantile hemangioma. Part 1: Epidemiology, pathogenesis, clinical presentation and assessment.婴儿血管瘤。第 1 部分:流行病学、发病机制、临床表现和评估。
J Am Acad Dermatol. 2021 Dec;85(6):1379-1392. doi: 10.1016/j.jaad.2021.08.019. Epub 2021 Aug 19.
4
Infantile hemangioma. Part 2: Management.婴儿血管瘤。第2部分:管理
J Am Acad Dermatol. 2021 Dec;85(6):1395-1404. doi: 10.1016/j.jaad.2021.08.020. Epub 2021 Aug 19.
5
Efficacy and safety of adrenergic beta-antagonist combined with lasers in the treatment of infantile hemangiomas: a meta-analysis.肾上腺素能β受体拮抗剂联合激光治疗婴幼儿血管瘤的疗效和安全性:荟萃分析。
Pediatr Surg Int. 2020 Oct;36(10):1135-1147. doi: 10.1007/s00383-020-04711-2. Epub 2020 Jul 9.
6
Systemic timolol exposure following topical application to infantile hemangiomas.局部应用于婴儿血管瘤后全身的噻吗洛尔暴露情况。
J Am Acad Dermatol. 2020 Mar;82(3):733-736. doi: 10.1016/j.jaad.2019.02.029. Epub 2019 Feb 18.
7
Central Effects of Beta-Blockers May Be Due to Nitric Oxide and Hydrogen Peroxide Release Independently of Their Ability to Cross the Blood-Brain Barrier.β受体阻滞剂的中枢效应可能归因于一氧化氮和过氧化氢的释放,与其穿越血脑屏障的能力无关。
Front Neurosci. 2019 Jan 31;13:33. doi: 10.3389/fnins.2019.00033. eCollection 2019.
8
Clinical Practice Guideline for the Management of Infantile Hemangiomas.婴幼儿血管瘤管理临床实践指南。
Pediatrics. 2019 Jan;143(1). doi: 10.1542/peds.2018-3475.
9
Unusual Cause of Pediatric Vaginal Bleeding: Infantile Capillary Hemangioma of the Cervix.小儿阴道出血的罕见原因:宫颈婴儿毛细血管瘤
J Pediatr Adolesc Gynecol. 2019 Feb;32(1):80-82. doi: 10.1016/j.jpag.2018.08.003. Epub 2018 Aug 11.
10
Oral propranolol in the treatment of proliferating infantile haemangiomas: British Society for Paediatric Dermatology consensus guidelines.口服普萘洛尔治疗增殖性婴儿血管瘤:英国儿科皮肤病学会共识指南。
Br J Dermatol. 2018 Sep;179(3):582-589. doi: 10.1111/bjd.16779.