Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.
Department of Infectious Diseases, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.
Postgrad Med J. 2024 Aug 16;100(1187):642-648. doi: 10.1093/postmj/qgae031.
Obesity is a crucial risk factor for asthma. Observational studies have examined the association between abdominal obesity and asthma symptoms. This study aimed to investigate the causal relationship between visceral adipose tissue (VAT) and asthma and its potential as an independent indicator.
This study utilized data from the National Health and Nutrition Examination Survey spanning 2011-8. Multivariable logistic regression and stratified variable selection were employed to identify associations between asthma and VAT. Moreover, a two-sample Mendelian randomization analysis, using 221 genetic variants as instrumental variables, was conducted to assess this relationship further.
Our findings indicated that individuals with higher VAT levels were more likely to develop asthma. Visceral obesity remained a significant risk factor for asthma after adjusting for demographic characteristics. Genetic predictions suggest a positive association between VAT and an elevated risk of asthma (odds ratio [OR] = 1.393, 95% confidence interval [CI]: 1.266-1.534, and P = 1.43E-11). No significant polymorphisms were detected using the Mendelian randomization-Egger intercept test.
This study presents potential evidence supporting the causal role of VAT in asthma development. Furthermore, the findings from the Mendelian randomization analysis further reinforce the relationship between VAT and asthma risk.
肥胖是哮喘的一个重要危险因素。观察性研究已经研究了腹型肥胖与哮喘症状之间的关系。本研究旨在探讨内脏脂肪组织（VAT）与哮喘之间的因果关系及其作为独立指标的潜力。
本研究利用了 2011-2018 年全国健康和营养调查的数据。采用多变量逻辑回归和分层变量选择来确定哮喘与 VAT 之间的关联。此外，还使用 221 个遗传变异作为工具变量进行两样本 Mendelian 随机化分析，以进一步评估这种关系。
我们的研究结果表明，VAT 水平较高的个体更容易患上哮喘。调整人口统计学特征后，内脏肥胖仍然是哮喘的一个重要危险因素。遗传预测表明 VAT 与哮喘风险升高之间存在正相关（比值比 [OR] = 1.393，95%置信区间 [CI]：1.266-1.534，P = 1.43E-11）。Mendelian 随机化-Egger 截距检验未发现显著的多态性。
本研究提供了潜在的证据支持 VAT 在哮喘发展中的因果作用。此外，Mendelian 随机化分析的结果进一步加强了 VAT 与哮喘风险之间的关系。
