Department of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital, Ningbo, China.
Department of Neurocritical Care Medicine, Ningbo Medical Center Lihuili Hospital, Ningbo, China.
Sci Rep. 2024 Oct 5;14(1):23217. doi: 10.1038/s41598-024-74297-5.
Asthma is a chronic inflammatory disease that affects millions of people worldwide. Obesity, particularly visceral adipose tissue (VAT), is known to secrete adipokines and pro-inflammatory factors, which are closely associated with various metabolic and cardiovascular diseases. Research indicates that these metabolic disturbances can exacerbate inflammatory conditions, contributing to both cardiovascular and respiratory diseases, including asthma. Despite these associations, studies on the specific relationship between VAT and asthma remain limited and warrant further investigation. Utilizing the NHANES database from 2011 to 2018, we included a total of 11,137 participants. Multivariable regression analysis was performed, stratifying subjects based on VAT levels and adjusting for various confounders. Subgroup interaction analysis and nonlinear analysis were conducted to explore potential effect modifiers and nonlinear associations. In this study, 11,137 participants were included, with 49.74% being female. Among the 509 asthma patients, 69.35% were female. The number of asthma patients among Non-Hispanic Whites was 212, representing 41.65% of the total, the highest proportion among the studied groups. The VAT for asthma patients was 529 g, significantly higher than the 455 g in the non-asthma group (P < 0.001). Multivariable regression analysis showed that for every 200 g increase in VAT, the risk of asthma increased by 10.4% (P = 0.032), 20.8% (P < 0.001), and 20.3% (P = 0.004) across three models (unadjusted, adjusted for demographic factors, and fully adjusted). Subgroup analysis indicated a stronger association between VAT and asthma risk in females and individuals over 40 years old. Nonlinear analysis uncovers a J-shaped relationship between VAT and asthma, with the lowest risk observed at 464.57 g (P < 0.001). The study findings suggest that increased VAT is associated with elevated asthma risk, particularly among females and older individuals. These results underscore the importance of considering VAT in asthma risk assessment and highlight potential targeted interventions to reduce asthma risk associated with excess visceral adiposity.
哮喘是一种影响全球数百万人的慢性炎症性疾病。肥胖，特别是内脏脂肪组织 (VAT)，已知会分泌脂肪因子和促炎因子，这些因子与各种代谢和心血管疾病密切相关。研究表明，这些代谢紊乱会加重炎症状况，导致心血管和呼吸系统疾病，包括哮喘。尽管存在这些关联，但关于 VAT 与哮喘之间具体关系的研究仍然有限，需要进一步研究。
我们利用 2011 年至 2018 年的 NHANES 数据库，共纳入了 11137 名参与者。采用多变量回归分析，根据 VAT 水平对受试者进行分层，并调整了各种混杂因素。进行了亚组交互分析和非线性分析，以探讨潜在的效应修饰因子和非线性关联。
在这项研究中，共纳入了 11137 名参与者，其中 49.74%为女性。在 509 名哮喘患者中，69.35%为女性。非西班牙裔白人中哮喘患者的数量为 212 人，占总人数的 41.65%，是研究人群中比例最高的。哮喘患者的 VAT 为 529g，明显高于非哮喘组的 455g（P<0.001）。多变量回归分析显示，VAT 每增加 200g，哮喘的风险增加 10.4%（P=0.032）、20.8%（P<0.001）和 20.3%（P=0.004），这三种模型分别为（未调整、调整人口统计学因素和完全调整）。亚组分析表明，VAT 与女性和 40 岁以上人群的哮喘风险之间存在更强的关联。非线性分析揭示了 VAT 与哮喘之间呈 J 形关系，在 464.57g 时风险最低（P<0.001）。
研究结果表明，VAT 增加与哮喘风险升高相关，尤其是在女性和老年人中。这些结果强调了在哮喘风险评估中考虑 VAT 的重要性，并突出了针对过多内脏脂肪的潜在靶向干预措施，以降低与哮喘相关的风险。
