Dölling Maximilian, Herrmann Martin, Boettcher Michael
Department of General, Visceral, Vascular and Transplant Surgery, University Hospital Magdeburg, 39120 Magdeburg, Germany.
Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Universitätsklinikum Erlangen, 91054 Erlangen, Germany.
Children (Basel). 2024 Mar 1;11(3):295. doi: 10.3390/children11030295.
This comprehensive review examines the role of Neutrophil Extracellular Traps (NETs) in pediatric surgery. Focusing on NET formation, functions, and implications, this study highlights their dual impact in infection control and contribution to tissue damage after surgery. It covers the role of NET formation in a range of pediatric conditions including immunothrombosis, formation of peritoneal adhesions, appendicitis, burns, gallstones, tumors, and necrotizing enterocolitis (NEC). The results underscore the significance of NETs in fighting infections and their association with complications like sepsis and delayed wound healing. The breakdown products of NETs as a diagnostic tool of the clinical course of acute appendicitis will also be discussed. Understanding NET formation in the pathophysiology can potentially help to find new therapeutic approaches such as the application of DNase and elastase inhibitors to change the clinical course of various diseases in pediatric surgery such as improvement of wound healing, adhesion formation, NEC, and many more.
这篇综述探讨了中性粒细胞胞外陷阱（NETs）在小儿外科中的作用。该研究聚焦于NET的形成、功能及影响，强调了它们在感染控制中的双重作用以及对术后组织损伤的影响。研究涵盖了NET形成在一系列儿科疾病中的作用，包括免疫血栓形成、腹膜粘连形成、阑尾炎、烧伤、胆结石、肿瘤和坏死性小肠结肠炎（NEC）。结果强调了NETs在对抗感染中的重要性及其与败血症和伤口愈合延迟等并发症的关联。NETs的分解产物作为急性阑尾炎临床病程的诊断工具也将进行讨论。了解病理生理学中的NET形成可能有助于找到新的治疗方法，如应用脱氧核糖核酸酶和弹性蛋白酶抑制剂来改变小儿外科各种疾病的临床病程，如改善伤口愈合、粘连形成、NEC等等。
