Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Int J Colorectal Dis. 2023 Apr 18;38(1):102. doi: 10.1007/s00384-023-04391-z.
There have been debates about the human appendix function, and while previous research suggested it might be a vestigial organ with no functional significance, recent studies have pointed out that it might have an important role in the immune system. Acute appendicitis (AA) is a common cause of emergency abdominal surgery in the world. Some epidemiologic investigations have found an association between appendicitis and viral infections. In this study, we have reviewed systematically articles to discover viral infections that cause appendicitis and find any possible correlations between the two.
This systematic review was performed by searching among electronic databases including Web of Science, PubMed, Scopus, and EMBASE on viruses and appendicitis topics.
Conducted search leads to 983 results in all databases after the duplicate removal and screening by title, abstract, and full-text based on inclusion criteria lead to 19 studies. There were several assays to detect the viruses, which are thought to be AA causative agents. RT-PCR and immunoassays were the mainstay methods to detect the probable cause.
Investigations suggested that some viruses including measles virus (MV), influenza virus, dengue fever virus (DFV), human immunodeficiency virus (HIV), human herpesviruses, rotavirus, and adenovirus are associated with acute appendicitis. Despite the available reports, the specific mechanisms behind the relationship between acute appendicitis and viral infections are yet to be understood. Therefore, further investigations are necessary to find out the pathogenesis and pathophysiology of viral complications in appendicitis.
关于人类阑尾的功能一直存在争议，虽然之前的研究表明它可能是一个没有功能意义的退化器官，但最近的研究指出，它可能在免疫系统中发挥重要作用。急性阑尾炎（AA）是世界范围内常见的紧急腹部手术原因。一些流行病学调查发现阑尾炎与病毒感染之间存在关联。在这项研究中，我们系统地回顾了文章，以发现引起阑尾炎的病毒，并发现两者之间可能存在的任何关联。
本系统评价通过在电子数据库中搜索，包括 Web of Science、PubMed、Scopus 和 EMBASE 中有关病毒和阑尾炎的主题。
在所有数据库中进行搜索后，去除重复项，并根据纳入标准通过标题、摘要和全文进行筛选，共得到 983 项结果，最终纳入 19 项研究。有几种检测病毒的方法被认为是 AA 的致病因素。逆转录聚合酶链反应（RT-PCR）和免疫测定是检测可能病因的主要方法。
研究表明，包括麻疹病毒（MV）、流感病毒、登革热病毒（DFV）、人类免疫缺陷病毒（HIV）、人类疱疹病毒、轮状病毒和腺病毒在内的一些病毒与急性阑尾炎有关。尽管有这些报道，但急性阑尾炎与病毒感染之间关系的确切机制仍有待理解。因此，需要进一步的研究来了解阑尾炎中病毒并发症的发病机制和病理生理学。
