Sport Sciences Research Centre, Rey Juan Carlos University, 28943 Fuenlabrada, Spain.
Medical Department & Barça Innovation Hub, Fútbol Club Barcelona, 08038 Barcelona, Spain.
Genes (Basel). 2024 Mar 21;15(3):386. doi: 10.3390/genes15030386.
The aim of this study was to investigate the association of the rs1815739 polymorphism with match running performance and injury incidence in top-level professional football players. A total of 315 top-level professional football players from the first division of Spanish football (i.e., ) participated in this prospective and descriptive study. The rs1815739 genotype was identified for each player using genomic DNA samples. During 2021-2022, players' performance was obtained through a validated camera system in all official matches. Additionally, the incidence of non-contact injuries was obtained by each team's medical staff according to the International Olympic Committee (IOC) statement. From the study sample, 116 (36.8%) players had the RR genotype, 156 (49.5%) had the RX genotype, and 43 (13.7%) had the XX genotype. The anthropometric characteristics of the players were similar across genotypes. However, the total running distance ( = 0.046), the distance at 21.0-23.9 km/h ( = 0.042), and the number of sprints ( = 0.042) were associated with the genotype. In all these variables, XX players had lower match performance values than RR players. Additionally, total and match injury incidences were higher in XX players than in RR players ( = 0.026 and 0.009, respectively). The rate of muscle injuries was also higher in XX players ( = 0.016). football players with the XX genotype had lower match running performance and a higher incidence of non-contact injuries over the season.
本研究旨在探究 rs1815739 多态性与顶级职业足球运动员比赛跑动表现和损伤发生率的相关性。共有 315 名来自西班牙足球甲级联赛的顶级职业足球运动员参与了这项前瞻性描述性研究。使用基因组 DNA 样本确定了每位运动员的 rs1815739 基因型。在 2021-2022 年期间，通过验证过的摄像系统获取了所有正式比赛中球员的表现数据。此外，根据国际奥委会（IOC）声明，由各队医务人员获取非接触性损伤的发生率。在研究样本中，116 名（36.8%）运动员为 RR 基因型，156 名（49.5%）为 RX 基因型，43 名（13.7%）为 XX 基因型。运动员的人体测量特征在各基因型间无显著差异。然而，总跑动距离（ = 0.046）、21.0-23.9km/h 的跑动距离（ = 0.042）和冲刺次数（ = 0.042）与 基因型相关。在所有这些变量中，XX 基因型运动员的比赛表现值均低于 RR 基因型运动员。此外，XX 基因型运动员的总损伤和比赛损伤发生率均高于 RR 基因型运动员（ = 0.026 和 0.009）。XX 基因型运动员的肌肉损伤发生率也更高（ = 0.016）。XX 基因型的足球运动员比赛跑动表现较低，赛季中非接触性损伤发生率较高。
