Affiliated Eye Hospital, Nanjing Medical University, Nanjing 210029, China.
The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing 210029, China.
Biomolecules. 2024 Mar 10;14(3):328. doi: 10.3390/biom14030328.
Ocular neovascularization can impair vision and threaten patients' quality of life. However, the underlying mechanism is far from transparent. In all mammals, macrophages are a population of cells playing pivotal roles in the innate immune system and the first line of defense against pathogens. Therefore, it has been speculated that the disfunction of macrophage homeostasis is involved in the development of ocular vascular diseases. Moreover, various studies have found that non-coding RNAs (ncRNAs) regulate macrophage homeostasis. This study reviewed past studies of the regulatory roles of ncRNAs in macrophage homeostasis in ocular vascular diseases.
眼内新生血管可损害视力并威胁患者的生活质量。然而，其潜在机制尚不清楚。在所有哺乳动物中，巨噬细胞是一群在先天免疫系统中发挥关键作用的细胞，也是抵御病原体的第一道防线。因此，有人推测巨噬细胞动态平衡的失调与眼部血管疾病的发生有关。此外，已有多项研究发现非编码 RNA（ncRNA）可调节巨噬细胞的动态平衡。本研究回顾了 ncRNA 对眼部血管疾病中巨噬细胞动态平衡的调控作用的相关研究。
