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新冠疫情对德国食管癌和胃癌手术的影响:一项对287例患者的四年回顾性单中心研究

The Impact of the COVID-19 Pandemic on Esophageal and Gastric Cancer Surgery in Germany: A Four-Year Retrospective Single-Center Study of 287 Patients.

作者信息

Ibach Marius, Winter Axel, Seika Philippa, Ritschl Paul, Berndt Nadja, Dobrindt Eva, Raakow Jonas, Pratschke Johann, Denecke Christian, Maurer Max Magnus

机构信息

Chirurgische Klinik, Campus Charité Mitte/Campus Virchow-Klinikum, Charité Universitätsmedizin Berlin, 13353 Berlin, Germany.

Berlin Institute of Health at Charité-Universitätsmedizin Berlin, BIH Biomedical Innovation Academy, BIH Charité Clinician Scientist Program, Charitéplatz 1, 10117 Berlin, Germany.

出版信息

J Clin Med. 2024 Mar 8;13(6):1560. doi: 10.3390/jcm13061560.

Abstract

Disruptions to surgical care for cancer patients during the COVID-19 pandemic remain an ongoing debate. This study assesses the effects of the COVID-19 pandemic on perioperative outcomes in a continuous series of surgically treated esophageal and gastric carcinoma patients at a large university hospital in Europe over 48 months. We conducted a retrospective single-center cohort study at a tertiary referral center. All patients who underwent oncologic esophageal or gastric resection between March 2018 and February 2022 were included in the analysis. The sample was split into a 24 months COVID-19 and an equivalent pre-COVID-19 control period. Outcome variables included caseload, in-hospital mortality, morbidity, treatment course, and disease stage at presentation. Surgeons performed 287 operations, with around two-thirds (62%) of the cohort undergoing esophagectomy and one-third (38%) gastrectomy. The in-hospital mortality was 1% for the COVID-19 and the control periods. Patients did not present at a later disease stage nor did they wait longer for treatment. There was no decrease in caseload, and patients did not suffer from more perioperative complications during COVID-19. Esophageal and gastric carcinoma patients received safe and timely surgical care during the pandemic. Future pandemic protocols may streamline oncologic care towards tertiary referral centers.

摘要

在新冠疫情期间,癌症患者手术治疗的中断仍是一个持续争论的话题。本研究评估了新冠疫情对欧洲一家大型大学医院连续48个月接受手术治疗的食管癌和胃癌患者围手术期结局的影响。我们在一家三级转诊中心进行了一项回顾性单中心队列研究。分析纳入了2018年3月至2022年2月期间接受肿瘤性食管或胃切除术的所有患者。样本被分为24个月的新冠疫情期和与之对应的新冠疫情前对照期。结局变量包括病例数、住院死亡率、发病率、治疗过程以及就诊时的疾病分期。外科医生共进行了287例手术,队列中约三分之二(62%)的患者接受了食管切除术,三分之一(38%)的患者接受了胃切除术。新冠疫情期和对照期的住院死亡率均为1%。患者就诊时疾病分期没有延迟,等待治疗的时间也没有延长。病例数没有减少,患者在新冠疫情期间也没有出现更多的围手术期并发症。食管癌和胃癌患者在疫情期间接受了安全及时的手术治疗。未来的疫情应对方案可能会使肿瘤治疗流程更趋向于三级转诊中心。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8417/10971404/b36245e4feec/jcm-13-01560-g001.jpg

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