Department of Geriatric Medicine and Memory Clinic, Research Center on Autonomy and Longevity CeRAL, University Hospital, 49000 Angers, France.
UNIV ANGERS, School of Medicine, Health Faculty, 49100 Angers, France.
Nutrients. 2024 Mar 15;16(6):856. doi: 10.3390/nu16060856.
The vitamin D status diagnosticator (VDSD), a 16-item tool, effectively identifies hypovitaminosis D in healthy older adults and can assist in determining the need for blood tests in this population. Assessing vitamin D levels is particularly crucial in the context of COVID-19. This study aimed to evaluate the VDSD's effectiveness in pinpointing hypovitaminosis D in older adults affected by COVID-19. The research involved 102 unsupplemented geriatric inpatients consecutively admitted to the acute geriatric division of Angers University Hospital, France, with an average age of 85.0 ± 5.9 years (47.1% women). The physician-administered VDSD was conducted simultaneously with the measurement of serum 25-hydroxyvitamin D (25(OH)D). Hypovitaminosis D was defined as a serum 25(OH)D concentration of ≤75 nmol/L for vitamin D insufficiency and ≤50 nmol/L for vitamin D deficiency. Results revealed that 87 participants (85.3%) had vitamin D insufficiency and 63 (61.8%) had vitamin D deficiency. The VDSD accurately identified vitamin D deficiency with an area under the curve (AUC) of 0.81 and an odds ratio (OR) of 40. However, its accuracy in identifying vitamin D insufficiency was lower (AUC = 0.57). In conclusion, the 16-item VDSD, a concise questionnaire, effectively identifies vitamin D deficiency in geriatric patients with COVID-19. This tool can be valuable in guiding the decision to administer vitamin D supplementation during the early stages of COVID-19.
维生素 D 状态诊断器 (VDSD) 是一个 16 项工具,可有效识别健康老年人的维生素 D 缺乏症,并可帮助确定该人群是否需要进行血液检查。在 COVID-19 背景下,评估维生素 D 水平尤为重要。本研究旨在评估 VDSD 在识别 COVID-19 老年患者维生素 D 缺乏症方面的有效性。该研究涉及法国昂热大学医院急性老年科连续收治的 102 名未补充的老年住院患者,平均年龄为 85.0±5.9 岁(47.1%为女性)。医生同时进行 VDSD 和血清 25-羟维生素 D(25(OH)D)测量。维生素 D 缺乏症定义为血清 25(OH)D 浓度≤75 nmol/L 为维生素 D 不足,≤50 nmol/L 为维生素 D 缺乏。结果显示,87 名参与者(85.3%)存在维生素 D 不足,63 名(61.8%)存在维生素 D 缺乏。VDSD 对维生素 D 缺乏症的识别具有较高的准确性(曲线下面积 [AUC] 为 0.81,优势比 [OR] 为 40),但对维生素 D 不足的识别准确性较低(AUC 为 0.57)。总之,16 项简洁的 VDSD 可有效识别 COVID-19 老年患者的维生素 D 缺乏症。该工具可用于指导 COVID-19 早期补充维生素 D 的决策。