Annweiler Cédric, Riou Jérémie, Alessandri Axel, Gicquel David, Henni Samir, Féart Catherine, Kabeshova Anastasiia
Department of Neurosciences and Aging, Division of Geriatric Medicine, Angers University Hospital, Angers University Memory Clinic, Research Center on Autonomy and Longevity, University of Angers, UPRES EA 4638, UNAM, 49035 Angers, France.
Department of Medical Biophysics, Robarts Research Institute, Schulich School of Medicine and Dentistry, the University of Western Ontario, London, ON N6A 3K7, Canada.
Nutrients. 2017 Jun 27;9(7):658. doi: 10.3390/nu9070658.
The 16-item Vitamin D Status Predictor (VDSP) tool identifies healthy older community-dwellers at risk of hypovitaminosis D and may guide the use of blood tests in this population. The objective of the present hospital-based study was to test the efficacy of the VDSP to identify geriatric patients with hypovitaminosis D. The study included 199 nonsupplemented geriatric in- and outpatients consecutively admitted to Angers University Hospital, France (mean ± SD, 82.0 ± 7.8 years; 53.3% female). Serum 25-hydroxyvitaminD (25(OH)D) was measured at the time of the physician-administered VDSP. Hypovitaminosis D was defined as serum 25(OH)D concentration ≤ 75 nmol/L for vitamin D insufficiency, 25(OH)D ≤ 50 nmol/L for vitamin D deficiency, and 25(OH)D ≤ 25 nmol/L for severe vitamin D deficiency. We found that 184 participants (92.4%) had vitamin D insufficiency, 136 (68.3%) had vitamin D deficiency, and 67 (33.7%) had severe vitamin D deficiency. The VDSP identified severe vitamin D deficiency with an area under curve (AUC) = 0.83 and OR = 24.0. The VDSP was able to identify vitamin D deficiency and vitamin D insufficiency with less accuracy (AUC = 0.71 and AUC = 0.73, respectively). In conclusion, the 16-item VDSP is a short questionnaire that accurately identifies geriatric patients with severe vitamin D deficiency. This tool may guide the use of blood collection for determining geriatric patients' vitamin D status.
16项维生素D状态预测工具(VDSP)可识别维生素D缺乏症风险的健康老年社区居民,并可指导该人群血液检测的使用。本项基于医院的研究目的是测试VDSP识别维生素D缺乏症老年患者的有效性。该研究纳入了199名未补充维生素D的法国昂热大学医院连续收治的老年住院和门诊患者(平均±标准差,82.0±7.8岁;53.3%为女性)。在医生进行VDSP评估时测量血清25-羟基维生素D(25(OH)D)。维生素D缺乏症定义为血清25(OH)D浓度≤75 nmol/L为维生素D不足,25(OH)D≤50 nmol/L为维生素D缺乏,25(OH)D≤25 nmol/L为严重维生素D缺乏。我们发现184名参与者(92.4%)有维生素D不足,136名(68.3%)有维生素D缺乏,67名(33.7%)有严重维生素D缺乏。VDSP识别严重维生素D缺乏的曲线下面积(AUC)=0.83,比值比(OR)=24.0。VDSP识别维生素D缺乏和维生素D不足的准确性较低(AUC分别为0.71和0.73)。总之,16项VDSP是一份简短问卷,可准确识别严重维生素D缺乏的老年患者。该工具可指导采血以确定老年患者的维生素D状态。