Oncology Unit, ASST Bergamo Ovest, Treviglio, BG, Italy.
Oncology Unit, ASST Bergamo Ovest, Treviglio, BG, Italy.
J Steroid Biochem Mol Biol. 2021 Jul;211:105883. doi: 10.1016/j.jsbmb.2021.105883. Epub 2021 Mar 26.
Vitamin D modulates the systemic inflammatory response through interaction with immune system. As such, it has a possible protective role against the risk of respiratory tract infections and other diseases. It may be useful in particular, during COVID-19 pandemic. PubMed, the Cochrane Library, and EMBASE were searched from inception until January 31, 2021, for observational or clinical studies reporting the prognosis (and therapeutic effect) of COVID-19 infection in patients with deficient vitamin D levels. The infection rate, severity, and death from COVID-19 infection were pooled to provide an odds ratio with a 95 % confidence interval (OR 95 % CI). An OR > 1 was associated with the worst outcome in deficient compared with nondeficient patients. We assessed the association between vitamin D and risk, severity, and mortality for COVID-19 infection, through a review of 43 observational studies. Among subjects with deficient vitamin D values, risk of COVID-19 infection was higher compared to those with replete values (OR = 1.26; 95 % CI, 1.19-1.34; P < .01). Vitamin D deficiency was also associated with worse severity and higher mortality than in nondeficient patients (OR = 2.6; 95 % CI, 1.84-3.67; P < .01 and OR = 1.22; 95 % CI, 1.04-1.43; P < .01, respectively). Reduced vitamin D values resulted in a higher infection risk, mortality and severity COVID-19 infection. Supplementation may be considered as preventive and therapeutic measure.
维生素 D 通过与免疫系统相互作用来调节全身炎症反应。因此，它可能对呼吸道感染和其他疾病的风险具有保护作用。在 COVID-19 大流行期间，它可能特别有用。从建库到 2021 年 1 月 31 日，我们在 PubMed、Cochrane 图书馆和 EMBASE 上检索了报告维生素 D 水平不足的 COVID-19 感染患者预后（和治疗效果）的观察性或临床研究。我们将感染率、严重程度和 COVID-19 感染死亡进行汇总，以提供比值比及其 95%置信区间（OR 95%CI）。与非缺乏患者相比，比值比（OR）>1 与较差的结局相关。我们通过对 43 项观察性研究的综述，评估了维生素 D 与 COVID-19 感染风险、严重程度和死亡率之间的关系。在维生素 D 值不足的患者中，COVID-19 感染的风险高于维生素 D 值充足的患者（OR=1.26；95%CI，1.19-1.34；P<.01）。与非缺乏患者相比，维生素 D 缺乏与更严重的疾病和更高的死亡率相关（OR=2.6；95%CI，1.84-3.67；P<.01 和 OR=1.22；95%CI，1.04-1.43；P<.01）。维生素 D 值降低导致 COVID-19 感染的感染风险、死亡率和严重程度增加。补充维生素 D 可能被认为是一种预防和治疗措施。
