生物催化合成香豆素-糖苷：用于生物医学成像和传感的非细胞毒性探针。
Biocatalytic Synthesis of Coumarin -Glycosides: Towards Non-Cytotoxic Probes for Biomedical Imaging and Sensing.
机构信息
Institut de Chimie Organique et Analytique, University of Orléans CNRS UMR7311, F-45067 Orléans, France.
Chaire de Cosmétologie, AgroParisTech, 10 rue Léonard de Vinci, F-45100 Orléans, France.
出版信息
Molecules. 2024 Mar 16;29(6):1322. doi: 10.3390/molecules29061322.
This study unveils an innovative method for synthesizing coumarin -glycosides, employing original biocatalysts able to graft diverse carbohydrate structures onto 7-mercapto-4-methyl-coumarin in one-pot reactions. The fluorescence properties of the generated thio-derivatives were assessed, providing valuable insights into their potential applications in biological imaging or sensing. In addition, the synthesized compounds exhibited no cytotoxicity across various human cell lines. This research presents a promising avenue for the development of coumarin -glycosides, paving the way for their application in diverse biomedical research areas.
本研究揭示了一种新颖的香豆素-糖苷合成方法，采用原创的生物催化剂能够在一锅反应中将各种碳水化合物结构接枝到 7-巯基-4-甲基香豆素上。对生成的硫代衍生物的荧光性质进行了评估，为它们在生物成像或传感中的潜在应用提供了有价值的见解。此外，合成的化合物在各种人源细胞系中均无细胞毒性。本研究为香豆素-糖苷的开发提供了一个有前途的途径，为它们在各种生物医学研究领域的应用铺平了道路。
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