• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

巯基香豆素的研究进展:合成与反应活性。

Insight on Mercapto-Coumarins: Synthesis and Reactivity.

机构信息

National Research Centre, Chemistry of Natural Compounds Department, Dokki, Cairo 12622, Egypt.

Plant Advanced Technologies (PAT), 54500 Vandœuvre-lès-Nancy, France.

出版信息

Molecules. 2022 Mar 26;27(7):2150. doi: 10.3390/molecules27072150.

DOI:10.3390/molecules27072150
PMID:35408548
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9000435/
Abstract

Mercapto (or sulfanyl)-coumarins are heterocycles of great interest in the development of valuable active structures in material and biological domains. They represent a highly exploitable class of compounds that open many possibilities for further chemical transformations. The present review aims to draw focus toward the synthetic applicability of various forms of mercapto-coumarins and their representations in pharmaceuticals and industries. This work covers the literature issued from 1970 to 2021.

摘要

巯基(或硫基)-香豆素是杂环化合物,在材料和生物领域开发有价值的活性结构方面具有重要意义。它们代表了一类具有高度可开发性的化合物,为进一步的化学转化提供了多种可能性。本综述旨在关注各种形式的巯基香豆素及其在制药和工业中的应用的合成适用性。这项工作涵盖了 1970 年至 2021 年发表的文献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/73f3afeca477/molecules-27-02150-sch037.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/d64a661cd635/molecules-27-02150-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/650b9fc55a03/molecules-27-02150-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/13e168794598/molecules-27-02150-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/48d7869d80ce/molecules-27-02150-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/183edd34f248/molecules-27-02150-sch004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/299b90f51e08/molecules-27-02150-sch005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/2f8b6b8ca741/molecules-27-02150-sch006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/34f305678b88/molecules-27-02150-sch007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/7c17fad708f4/molecules-27-02150-sch008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/83307a0c9ab0/molecules-27-02150-sch009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/6bc013b4c8cf/molecules-27-02150-sch010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/adf45e78ad48/molecules-27-02150-sch011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/5f02444758b1/molecules-27-02150-sch012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/9a08a50cf6a6/molecules-27-02150-sch013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/cf85df21eba8/molecules-27-02150-sch014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/03f5149890cf/molecules-27-02150-sch015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/3965e1b0216d/molecules-27-02150-sch016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/9076c62aa822/molecules-27-02150-sch017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/65db4548d48a/molecules-27-02150-sch018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/97d17cf6aacf/molecules-27-02150-sch019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/7bed64cd3fd7/molecules-27-02150-sch020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/ab7f28d61dd0/molecules-27-02150-sch021.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/b5cd6bd4a613/molecules-27-02150-sch022.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/ad2a41875234/molecules-27-02150-sch023.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/e888715e7115/molecules-27-02150-sch024.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/ccad7a577a9e/molecules-27-02150-sch025.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/acd5362f21f7/molecules-27-02150-sch026.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/437dbb8c5300/molecules-27-02150-sch027.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/6984b2340545/molecules-27-02150-sch028.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/b9651f2f1c34/molecules-27-02150-sch029.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/f95c81c17f4c/molecules-27-02150-sch030.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/2da485cc57f2/molecules-27-02150-sch031.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/f32cf0801656/molecules-27-02150-sch032.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/5e7d78ae54af/molecules-27-02150-sch033.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/bf15e2de513f/molecules-27-02150-sch034.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/47e2e5336e4e/molecules-27-02150-sch035.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/db885cb039aa/molecules-27-02150-sch036.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/73f3afeca477/molecules-27-02150-sch037.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/d64a661cd635/molecules-27-02150-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/650b9fc55a03/molecules-27-02150-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/13e168794598/molecules-27-02150-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/48d7869d80ce/molecules-27-02150-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/183edd34f248/molecules-27-02150-sch004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/299b90f51e08/molecules-27-02150-sch005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/2f8b6b8ca741/molecules-27-02150-sch006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/34f305678b88/molecules-27-02150-sch007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/7c17fad708f4/molecules-27-02150-sch008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/83307a0c9ab0/molecules-27-02150-sch009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/6bc013b4c8cf/molecules-27-02150-sch010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/adf45e78ad48/molecules-27-02150-sch011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/5f02444758b1/molecules-27-02150-sch012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/9a08a50cf6a6/molecules-27-02150-sch013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/cf85df21eba8/molecules-27-02150-sch014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/03f5149890cf/molecules-27-02150-sch015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/3965e1b0216d/molecules-27-02150-sch016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/9076c62aa822/molecules-27-02150-sch017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/65db4548d48a/molecules-27-02150-sch018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/97d17cf6aacf/molecules-27-02150-sch019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/7bed64cd3fd7/molecules-27-02150-sch020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/ab7f28d61dd0/molecules-27-02150-sch021.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/b5cd6bd4a613/molecules-27-02150-sch022.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/ad2a41875234/molecules-27-02150-sch023.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/e888715e7115/molecules-27-02150-sch024.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/ccad7a577a9e/molecules-27-02150-sch025.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/acd5362f21f7/molecules-27-02150-sch026.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/437dbb8c5300/molecules-27-02150-sch027.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/6984b2340545/molecules-27-02150-sch028.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/b9651f2f1c34/molecules-27-02150-sch029.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/f95c81c17f4c/molecules-27-02150-sch030.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/2da485cc57f2/molecules-27-02150-sch031.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/f32cf0801656/molecules-27-02150-sch032.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/5e7d78ae54af/molecules-27-02150-sch033.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/bf15e2de513f/molecules-27-02150-sch034.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/47e2e5336e4e/molecules-27-02150-sch035.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/db885cb039aa/molecules-27-02150-sch036.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3be/9000435/73f3afeca477/molecules-27-02150-sch037.jpg

相似文献

1
Insight on Mercapto-Coumarins: Synthesis and Reactivity.巯基香豆素的研究进展:合成与反应活性。
Molecules. 2022 Mar 26;27(7):2150. doi: 10.3390/molecules27072150.
2
Coumarins as antioxidants.香豆素类作为抗氧化剂。
Curr Med Chem. 2011;18(25):3929-51. doi: 10.2174/092986711803414395.
3
A review: Biologically active 3,4-heterocycle-fused coumarins.综述:具有生物活性的 3,4-杂环并合香豆素。
Eur J Med Chem. 2021 Feb 15;212:113034. doi: 10.1016/j.ejmech.2020.113034. Epub 2020 Nov 25.
4
Semisynthesis of Selenoauraptene.硒金合欢醇的半合成
Molecules. 2021 May 10;26(9):2798. doi: 10.3390/molecules26092798.
5
New insights into the chemistry and antioxidant activity of coumarins.香豆素的化学性质与抗氧化活性新见解
Curr Top Med Chem. 2014;14(22):2600-23. doi: 10.2174/1568026614666141203144551.
6
Synthetic and natural coumarins as antioxidants.合成与天然香豆素类化合物作为抗氧化剂
Mini Rev Med Chem. 2006 Apr;6(4):365-74. doi: 10.2174/138955706776361457.
7
Synthetic and natural coumarins as cytotoxic agents.合成与天然香豆素作为细胞毒性剂
Curr Med Chem Anticancer Agents. 2005 Jan;5(1):29-46. doi: 10.2174/1568011053352550.
8
Simple coumarins and analogues in medicinal chemistry: occurrence, synthesis and biological activity.药物化学中的简单香豆素及其类似物:存在、合成与生物活性
Curr Med Chem. 2005;12(8):887-916. doi: 10.2174/0929867053507315.
9
Synthesis and Chemical Properties of 3-Phosphono-coumarins and 1,2-Benzoxaphosphorins as Precursors for Bioactive Compounds.3-膦酰基香豆素和 1,2-苯并氧磷杂环戊二烯的合成及化学性质作为生物活性化合物的前体。
Molecules. 2019 May 28;24(11):2030. doi: 10.3390/molecules24112030.
10
Structure-activity relationships of new 4-hydroxy bis-coumarins as radical scavengers and chain-breaking antioxidants.新型 4-羟基二苯并吡喃酮类化合物作为自由基清除剂和链终止抗氧化剂的构效关系。
Biochimie. 2010 Sep;92(9):1138-46. doi: 10.1016/j.biochi.2010.02.033. Epub 2010 Mar 6.

引用本文的文献

1
Synthesis, biofilm formation inhibitory, and inflammation inhibitory activities of new coumarin derivatives.新型香豆素衍生物的合成、生物膜形成抑制和炎症抑制活性。
Sci Rep. 2024 Apr 20;14(1):9106. doi: 10.1038/s41598-024-59072-w.
2
Biocatalytic Synthesis of Coumarin -Glycosides: Towards Non-Cytotoxic Probes for Biomedical Imaging and Sensing.生物催化合成香豆素-糖苷:用于生物医学成像和传感的非细胞毒性探针。
Molecules. 2024 Mar 16;29(6):1322. doi: 10.3390/molecules29061322.

本文引用的文献

1
Development of a candidate reference sample for the characterization of tip-enhanced Raman spectroscopy spatial resolution.用于表征针尖增强拉曼光谱空间分辨率的候选参考样品的研制。
RSC Adv. 2018 Aug 3;8(49):27863-27869. doi: 10.1039/c8ra03762k. eCollection 2018 Aug 2.
2
Synthesis and application of coumarin fluorescence probes.香豆素荧光探针的合成与应用
RSC Adv. 2020 Mar 17;10(18):10826-10847. doi: 10.1039/c9ra10290f. eCollection 2020 Mar 11.
3
The Two-Steps Reaction Fluorescent Probe for the Selective Detection of Cysteine and Its Applications.
两步反应荧光探针用于半胱氨酸的选择性检测及其应用。
Chem Biodivers. 2022 Feb;19(2):e202100862. doi: 10.1002/cbdv.202100862. Epub 2022 Jan 13.
4
Coumarin-benzimidazole hybrids: A review of developments in medicinal chemistry.香豆素-苯并咪唑杂合体:药物化学发展综述。
Eur J Med Chem. 2022 Jan 5;227:113921. doi: 10.1016/j.ejmech.2021.113921. Epub 2021 Oct 20.
5
Structural Features of a Family of Coumarin-Enamine Fluorescent Chemodosimeters for Ion Pairs.香豆素-烯胺荧光化学计量比型离子对试剂的结构特征。
Inorg Chem. 2021 Sep 20;60(18):14238-14252. doi: 10.1021/acs.inorgchem.1c01734. Epub 2021 Sep 1.
6
Coumarin Derivatives Act as Novel Inhibitors of Human Dipeptidyl Peptidase III: Combined In Vitro and In Silico Study.香豆素衍生物作为人二肽基肽酶III的新型抑制剂:体外和计算机模拟联合研究
Pharmaceuticals (Basel). 2021 Jun 5;14(6):540. doi: 10.3390/ph14060540.
7
Size-Dependent Penetration of Gold Nanoprobes into Fixed Cells.金纳米探针进入固定细胞的尺寸依赖性穿透
ACS Omega. 2021 Jan 28;6(5):3791-3799. doi: 10.1021/acsomega.0c05458. eCollection 2021 Feb 9.
8
Thioglycoligation of aromatic thiols using a natural glucuronide donor.使用天然葡糖醛酸供体对芳香硫醇进行硫代糖基化反应。
Org Biomol Chem. 2020 Aug 7;18(29):5582-5585. doi: 10.1039/d0ob00226g. Epub 2020 Jul 16.
9
In situ seed-growth synthesis of silver nanoplates on glass for the detection of food contaminants by surface enhanced Raman scattering.在玻璃上原位种子生长合成银纳米板,用于通过表面增强拉曼散射检测食物污染物。
Talanta. 2020 Aug 15;216:120936. doi: 10.1016/j.talanta.2020.120936. Epub 2020 Mar 19.
10
Coumarins in Food and Methods of Their Determination.食品中的香豆素及其测定方法。
Foods. 2020 May 18;9(5):645. doi: 10.3390/foods9050645.