Ferreira Andressa Coelho, Marques Raphael Furtado, Cunha Icaro Rodrigo Dutra, Moura Jhonata Costa, Oliveira Rebekha Matos, Farias Da Luz Kellen De Jesus, Silva Ludmila Tavares Dos Santos, de Carvalho Mateus Balbino Barbosa, Andrade Lara Possapp, Xavier Júlia Karla de Albuquerque Melo, Diniz Filho Joel Felix Silva, Rocha Cláudia Quintino, Ribeiro Rachel Melo
Biotechnology Graduate ProgramRENORBIO, Federal University of Maranhão, São Luís 65080-805, Brazil.
Health Science Graduate Program, Federal University of Maranhão, Campus São Luís, São Luís 65080-805, Brazil.
ACS Omega. 2025 Aug 27;10(35):39371-39397. doi: 10.1021/acsomega.5c02027. eCollection 2025 Sep 9.
(Cham.) L.G. Lohmann is a species endemic to the Brazilian Cerrado, commonly known as "cervejinha do campo," "cipó-una," or 'tintureiro," traditionally used to treat kidney stones and joint pain. This species has garnered scientific interest due to its potential pharmacological properties. This review evaluated the pharmacological effects of crude extracts and isolated compounds from , as well as its ethnopharmacological relevance. A comprehensive literature search was conducted across PubMed, Scielo, and Google Scholar for studies published between October 2014 and December 2024, using the descriptors "" and "" combined with terms related to , , and ethnopharmacological research. Of 896 records, 20 studies met the inclusion criteria. The included studies conducted comprehensive isolation and structural elucidation of the bioactive compounds, confirming their chemical identities and supporting their pharmacological relevance through robust analytical and spectroscopic validation. Different extracts and isolated compounds from the roots, leaves, and flowers of have antiulcerogenic, antitumor, antiproliferative, anti-inflammatory, and antifungal action. Brachydins demonstrated cytotoxicity against prostate cancer cells and exhibited biological potential against intracellular amastigotes of . Luteolin reduced proliferation in U-251 glioblastoma cells with low toxicity to nontumor cells. Additionally, the microemulsion and encapsulation of the active fraction obtained from the roots of this plant showed relevant biological activity for pharmaceutical applications. However, despite these promising findings, potential mutagenic effects raise concerns about the safety of using the plant. In conclusion, and its phytochemicals hold significant therapeutic and technological potential. Nevertheless, further studies are necessary to ensure safety and better understand its pharmacological mechanisms, thereby paving the way for the development of novel therapeutic agents derived from this species.
（Cham.）L.G. Lohmann是巴西塞拉多地区的特有物种，通常被称为“cervejinha do campo”、“cipó-una”或“tintureiro”，传统上用于治疗肾结石和关节疼痛。由于其潜在的药理特性，该物种引起了科学界的兴趣。本综述评估了该植物粗提物和分离化合物的药理作用及其民族药理学相关性。在PubMed、Scielo和谷歌学术上进行了全面的文献检索，以查找2014年10月至2024年12月期间发表的研究，使用描述符“L.G. Lohmann”以及与植物化学、药理学和民族药理学研究相关的术语。在896条记录中，有20项研究符合纳入标准。纳入的研究对生物活性化合物进行了全面的分离和结构解析，通过可靠的分析和光谱验证确定了它们的化学身份并支持其药理相关性。从L.G. Lohmann的根、叶和花中提取的不同提取物和分离化合物具有抗溃疡、抗肿瘤、抗增殖、抗炎和抗真菌作用。Brachydins对前列腺癌细胞具有细胞毒性，并对杜氏利什曼原虫的细胞内无鞭毛体具有生物活性。木犀草素可降低U-251胶质母细胞瘤细胞的增殖，对非肿瘤细胞毒性较低。此外，从该植物根部获得的活性成分的微乳剂和包封物在药物应用中显示出相关的生物活性。然而，尽管有这些有前景的发现，但潜在的诱变作用引发了对使用该植物安全性的担忧。总之，L.G. Lohmann及其植物化学物质具有显著的治疗和技术潜力。然而，需要进一步的研究以确保安全性并更好地理解其药理机制，从而为开发源自该物种的新型治疗药物铺平道路。
