从唐松草属植物黑紫唐松草根茎中分离得到的两种新甾体生物碱及其抗 TYLCV 活性。
Two new steroidal alkaloids from the rhizomes of Veratrum nigrum L. and their anti-TYLCV activity.
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; University of Chinese Academy of Sciences, Beijing 100049, China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
出版信息
Fitoterapia. 2020 Nov;147:104731. doi: 10.1016/j.fitote.2020.104731. Epub 2020 Sep 23.
Two new steroidal alkaloids (1-2), together with seven known related steroidal alkaloids (3-9), were isolated from the rhizomes of Veratrum nigrum L. Their structures were elucidated by extensive spectroscopic analysis, and by comparison with literature data. Compound 1 possessed a rare 1, 3-oxazolidine unit within varazine-type alkaloids, and 2 was a 9-hydroxy-4-one derivative of 3-veratroylgermine. All isolates were evaluated inhibit tomato yellow leaf curl virus (TYLCV) activity. Compounds 5 and 7 (40 μg/mL) showed a significant anti-TYLCV activity in the host Nicotiana benthamiana with inhibition rates 74.6% and 63.4%, respectively, which are higher than that of the positive control ningnanmycin (51.4%).
从百合科藜芦属植物黑藜芦的根茎中分离得到了两个新的甾体生物碱（1-2），以及 7 个已知的甾体生物碱（3-9）。通过广泛的光谱分析，并与文献数据进行比较，确定了它们的结构。化合物 1 在 varazine 型生物碱中具有罕见的 1,3-恶唑烷单元，化合物 2 是 3-藜芦酰基 germine 的 9-羟基-4-酮衍生物。所有分离物均评估了对番茄黄曲叶病毒（TYLCV）的抑制活性。化合物 5 和 7（40μg/mL）在宿主烟草原生质体中表现出显著的抗 TYLCV 活性，抑制率分别为 74.6%和 63.4%，均高于阳性对照宁南霉素（51.4%）。
Zotero 插件