Akinyamoju Akindayo Olufunto, Akinloye Seyi John, Okiti Robinson Obos, Adeyemi Bukola Folasade
Dept. of Oral Pathology, University of Ibadan, University College Hospital, Ibadan, Oyo State, Nigeria.
Dept. of Oral Pathology, University College Hospital, Ibadan, Oyo State, Nigeria.
J Dent (Shiraz). 2024 Mar 1;25(1):32-38. doi: 10.30476/dentjods.2023.96389.1935. eCollection 2024 Mar.
Fibro-osseous lesions (FLs), may rarely exhibit malignant features likewise undergo malignant transformation. Awareness of these features can assist in screening for potentially malignant cases and identifying low-grade central osteogenic sarcoma (LGCOS) that may mimic FLs.
The objective of this study was to determine the usability of an index in predicting malignant changes in jaw FLs.
This was a retrospective study where hematoxylin and eosin (H&E) slides and archival records of fibrous dysplasia (FD) and ossifying fibroma (OF) cases were reviewed. The sections were assessed for permeation of marrow spaces, stromal growth pattern, cytologic atypia, mitotic activity, and pattern of bone growth, which are parameters for diagnosing LGCOS. The predictive histologic index of malignancy (PHIM) was determined by a sum of the scores and graded as 0=nil, 1=low, 2 & 3=moderate, and 4 & 5=high. Data were presented using descriptive analysis.
Ninety-three cases of FLs met the inclusion criteria, consisting of 40(43%) cases of FD and 53(57%) cases of OF. The peak age of presentation for FD and OF was 2 and 3 decade. There was a female preponderance of 1:1.6. The maxilla was the most common site affected by FD, while the mandible was most commonly affected by OF. For FD cases, the PHIM was moderate in 10(25%) cases and low in 21(52.5%) cases. Similarly, for OF cases, 30(56.6%) cases had low grade PHIM while 10(17%) cases had moderate grade PHIM.
The PHIM depicted low to moderate malignancy grade in some of the cases studied. Follow up studies would be necessary to assess the PHIM.
纤维-骨病变（FLs）可能很少表现出恶性特征，同样也会发生恶性转化。认识这些特征有助于筛查潜在的恶性病例，并识别可能模仿FLs的低级别中央骨肉瘤（LGCOS）。
本研究的目的是确定一种指标在预测颌骨FLs恶性变化中的可用性。
这是一项回顾性研究，对苏木精和伊红（H&E）切片以及纤维发育异常（FD）和骨化性纤维瘤（OF）病例的存档记录进行了回顾。对切片评估骨髓腔浸润、基质生长模式、细胞异型性、有丝分裂活性和骨生长模式，这些是诊断LGCOS的参数。通过分数总和确定预测性组织学恶性指数（PHIM），并分级为0 =无、1 =低、2和3 =中度、4和5 =高。使用描述性分析呈现数据。
93例FLs病例符合纳入标准，包括40例（43%）FD和53例（57%）OF。FD和OF的发病高峰年龄分别为20岁和30岁。女性占优势，比例为1:1.6。上颌骨是FD最常累及的部位，而下颌骨是OF最常累及的部位。对于FD病例，10例（25%）的PHIM为中度，21例（52.5%）为低度。同样，对于OF病例，30例（56.6%）的PHIM为低级别，10例（17%）为中级别。
在所研究的一些病例中，PHIM显示为低至中度恶性等级。有必要进行后续研究以评估PHIM。
