Zhou Yiyue, Yao Yi, Feng Yumei, Qiu Zhiyuan, Luo Shixian, Shi Xinyu, Gu Dandan, Jiang Maorong, Cai Min, Yao Dengbing
School of Life Sciences, Jiangsu Key Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong University, 19 Qixiu Road, Nantong, Jiangsu 226001, China.
Nantong University Xinglin College, Nantong, Jiangsu Province, China.
IBRO Neurosci Rep. 2024 Mar 6;16:455-467. doi: 10.1016/j.ibneur.2024.02.008. eCollection 2024 Jun.
To investigate the regulatory effect of Fas-L on the repair and regeneration of peripheral extension injury in rats.
This study aimed to explore the effects of Fas-L on apoptosis and axonal regeneration of dorsal root ganglion (DRG) cells in rat peripheral nerve repair and regeneration by using several relevant experimental techniques from the injured nerve animal model, cell biology, and molecular biology.
The expression level of Fas-L in DRG tissues was significantly down-regulated after sciatic nerve injury. Interference with Fas-L can significantly promote the regeneration of DRG neuronal axons and inhibit apoptosis, while the overexpression of Fas-L is contrary to it. Moreover, Fas-L may play a role in the regulation of DRG function and the repair and regeneration of peripheral nerves in Sprague Dawley (SD) rats by affecting several signaling pathways, such as p-AKT/AKT, β-catenin, and NF-κB.
Fas-L may have a certain effect on the repair and regeneration of peripheral nerve injury in SD rats, which may provide an experimental basis and a new theoretical basis for the functional reconstruction of peripheral nerves.
The expression level of Fas-L in DRG tissues was significantly down-regulated after sciatic nerve injury. Fas-L can significantly promote the regeneration of DRG neuronal axons and inhibit apoptosis. Fas-L may play a role in the regulation of DRG function and the repair and regeneration of peripheral nerves in SD rats by affecting several signaling pathways, such as p-AKT/AKT, β-catenin, and NF-κB. Fas-L may have a certain effect on the repair and regeneration of peripheral nerve injury in SD rats, which may provide an experimental basis and a new theoretical basis for the functional reconstruction of peripheral nerves.
探讨Fas-L对大鼠周围神经伸展性损伤修复与再生的调节作用。
本研究旨在通过使用来自损伤神经动物模型、细胞生物学和分子生物学的几种相关实验技术，探讨Fas-L对大鼠周围神经修复与再生中背根神经节（DRG）细胞凋亡和轴突再生的影响。
坐骨神经损伤后，DRG组织中Fas-L的表达水平显著下调。干扰Fas-L可显著促进DRG神经元轴突的再生并抑制凋亡，而Fas-L的过表达则相反。此外，Fas-L可能通过影响p-AKT/AKT、β-连环蛋白和NF-κB等多种信号通路，在调节SD大鼠DRG功能及周围神经的修复与再生中发挥作用。
Fas-L可能对SD大鼠周围神经损伤的修复与再生有一定作用，这可能为周围神经功能重建提供实验依据和新的理论基础。
坐骨神经损伤后，DRG组织中Fas-L的表达水平显著下调。Fas-L可显著促进DRG神经元轴突的再生并抑制凋亡。Fas-L可能通过影响p-AKT/AKT、β-连环蛋白和NF-κB等多种信号通路，在调节SD大鼠DRG功能及周围神经的修复与再生中发挥作用。Fas-L可能对SD大鼠周围神经损伤的修复与再生有一定作用，这可能为周围神经功能重建提供实验依据和新的理论基础。
