Ansari Rana Tabassum, Syed Uneeba, Riaz Musarrat, Askari Saima, Anjum Sarwat
Rana Tabassum Ansari, FCPS. Fellow Endocrine, Baqai Institute of Diabetology and Endocrinology, Baqai Medical University, Karachi, Pakistan.
Uneeba Syed, FCPS. Assistant Professor, Consultant Endocrinologist, Allama Iqbal Medical College, Jinnah hospital, Lahore, Pakistan.
Pak J Med Sci. 2024 Mar-Apr;40(4):736-740. doi: 10.12669/pjms.40.4.8271.
Hirsutism is a common endocrine disorder and its etiology varies from benign and idiopathic disorders to serious malignant diseases. Hirsutism creates negative impact on quality of life and considerable effects on fertility. Our objective was to determine the various causes of hirsutism in women presenting at two endocrine clinics.
This cross-sectional study was conducted at Baqai Institute of Diabetology and Endocrinology, Karachi and at Jinnah hospital, Lahore from August 2020 to December 2021 women between 12-45 years of age with complains of hirsutism were included in the study. Severity of Hirsutism was evaluated using modified Ferriman-Gallwey score (FG). Patients with modified FG score of 8 or more were considered having hirsutism.
The study had 113 patients with a mean age of 15.50+7.29 years with 89% having moderate hirsutism (FG score 16-25). Polycystic ovaries was the most common cause of hirsutism. Common sites for hirsutism included back (83%), arms (74%), buttocks (70%), and upper abdomen (47%). High BMI (p-value <0.01) and high Dehydroepiandrosterone levels were positively associated with the severity of hirsutism (p-value of 0.006.).
The various causes of hirsutism identified were polycystic ovaries, followed by idiopathic, thyroid dysfunction, congenital adrenal hyperplasia, and hyperprolactinemia; therefore, all women presenting with hirsutism should be evaluated for potential serious and curable etiologies, before embarking on a treatment plan.
多毛症是一种常见的内分泌紊乱疾病，其病因从良性和特发性疾病到严重的恶性疾病各不相同。多毛症会对生活质量产生负面影响，并对生育能力有显著影响。我们的目的是确定在两家内分泌诊所就诊的女性多毛症的各种病因。
这项横断面研究于2020年8月至2021年12月在卡拉奇的巴凯糖尿病与内分泌研究所和拉合尔的真纳医院进行，纳入了年龄在12 - 45岁之间、主诉有多毛症的女性。使用改良的费里曼 - 盖尔维评分（FG）评估多毛症的严重程度。改良FG评分为8分或更高的患者被认为患有多毛症。
该研究有113名患者，平均年龄为15.50 + 7.29岁，89%的患者有多毛症中度（FG评分16 - 25）。多囊卵巢是多毛症最常见的原因。多毛症的常见部位包括背部（83%）、手臂（74%）、臀部（70%）和上腹部（47%）。高体重指数（p值<0.01）和高脱氢表雄酮水平与多毛症的严重程度呈正相关（p值为0.006）。
已确定的多毛症的各种病因依次为多囊卵巢、其次是特发性、甲状腺功能障碍、先天性肾上腺皮质增生和高泌乳素血症；因此，所有出现多毛症的女性在开始治疗方案之前，都应评估是否存在潜在的严重且可治愈的病因。
