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一例高危多心肺合并症患者因大容量肠道准备继发肺水肿的病例报告

A Case Report of Pulmonary Edema Secondary to Large Volume Bowel Preparation in a High-Risk Patient with Multiple Cardiopulmonary Co-Morbidities.

作者信息

Fansiwala Kush, Prakash Preeti, Coe Christopher L, Weiss Guy A

机构信息

Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

Department of Hospital Medicine, Massachusetts General Hospital, Boston, MA, USA.

出版信息

Case Rep Gastroenterol. 2024 Mar 27;18(1):176-180. doi: 10.1159/000538158. eCollection 2024 Jan-Dec.

DOI:10.1159/000538158
PMID:38545369
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10972573/
Abstract

INTRODUCTION

Polyethylene glycol 3,350 and electrolytes is a commonly prescribed bowel regimen for colonoscopy preparation with an overall excellent safety profile, though prior reports have demonstrated risk of volume overload.

CASE PRESENTATION

A 55-year-old man with significant cardiopulmonary co-morbidities was admitted for acute hypoxic respiratory failure and subsequent evaluation for lung transplant. As part of his pretransplant evaluation, colon cancer screening was advised. Despite multiple days of bowel preparation, his stools contained sediment. Unfortunately, he developed pulmonary edema due to prolonged bowel preparation.

CONCLUSION

While bowel preparation is considered generally safe, our case report highlights the importance of judicious use with monitoring in high-risk individuals.

摘要

引言

聚乙二醇3350和电解质是结肠镜检查准备中常用的肠道准备方案,总体安全性良好,尽管先前的报告显示存在容量超负荷风险。

病例介绍

一名患有严重心肺合并症的55岁男性因急性低氧性呼吸衰竭入院,随后接受肺移植评估。作为移植前评估的一部分,建议进行结肠癌筛查。尽管进行了多天的肠道准备,他的粪便仍含有沉淀物。不幸的是,由于长时间的肠道准备,他出现了肺水肿。

结论

虽然肠道准备通常被认为是安全的,但我们的病例报告强调了在高危个体中谨慎使用并进行监测的重要性。

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本文引用的文献

1
A non-randomised single centre cohort study, comparing standard and modified bowel preparations, in adults with cystic fibrosis requiring colonoscopy.一项比较标准和改良肠道准备的非随机单中心队列研究,纳入需要结肠镜检查的成年囊性纤维化患者。
BMC Gastroenterol. 2019 Jun 13;19(1):89. doi: 10.1186/s12876-019-0979-z.
2
4-Liter split-dose polyethylene glycol is superior to other bowel preparations, based on systematic review and meta-analysis.4 升分剂量聚乙二醇优于其他肠道准备,基于系统评价和荟萃分析。
Clin Gastroenterol Hepatol. 2012 Nov;10(11):1225-31. doi: 10.1016/j.cgh.2012.08.029. Epub 2012 Aug 30.
3
Can a bowel preparation exacerbate heart failure?肠道准备会加重心力衰竭吗?
Cleve Clin J Med. 2011 Mar;78(3):157-60. doi: 10.3949/ccjm.77a.10025.
4
Mechanism of action and toxicities of purgatives used for colonoscopy preparation.泻药用于结肠镜检查准备的作用机制和毒性。
Expert Opin Drug Metab Toxicol. 2011 Jan;7(1):89-101. doi: 10.1517/17425255.2011.542411.
5
Low-volume PEG plus ascorbic acid versus high-volume PEG as bowel preparation for colonoscopy.低容量聚乙二醇加抗坏血酸与高容量聚乙二醇用于结肠镜检查肠道准备的比较。
Scand J Gastroenterol. 2010 Nov;45(11):1380-6. doi: 10.3109/00365521003734158. Epub 2010 Jul 5.
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A consensus document on bowel preparation before colonoscopy: prepared by a task force from the American Society of Colon and Rectal Surgeons (ASCRS), the American Society for Gastrointestinal Endoscopy (ASGE), and the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES).一份关于结肠镜检查前肠道准备的共识文件:由美国结肠和直肠外科医师协会(ASCRS)、美国胃肠内镜学会(ASGE)以及美国胃肠和内镜外科医师学会(SAGES)的一个特别工作组编写。
Gastrointest Endosc. 2006 Jun;63(7):894-909. doi: 10.1016/j.gie.2006.03.918.
7
Fulminant pulmonary oedema after administration of a balanced electrolyte polyethylene glycol solution.给予平衡电解质聚乙二醇溶液后发生暴发性肺水肿。
Arch Dis Child. 2002 Mar;86(3):209. doi: 10.1136/adc.86.3.209.
8
Exacerbation of congestive heart failure after administration of polyethylene glycol-electrolyte lavage solution.使用聚乙二醇电解质灌洗液后充血性心力衰竭加重。
Ann Pharmacother. 1995 Dec;29(12):1232-35. doi: 10.1177/106002809502901208.
9
Acute pulmonary edema after polyethylene glycol intestinal lavage in a child.一名儿童在聚乙二醇肠道灌洗后发生急性肺水肿。
Ann Pharmacother. 1993 Sep;27(9):1044-7. doi: 10.1177/106002809302700905.
10
The effect of polyethylene glycol gavage on plasma volume.聚乙二醇灌胃对血浆容量的影响。
J Surg Res. 1994 Aug;57(2):284-8. doi: 10.1006/jsre.1994.1146.