一种胃蛋白酶抑制性五肽（胃蛋白酶抑制剂）治疗十二指肠溃疡的双盲随机临床试验。
Double-blind randomised clinical trial of a pepsin-inhibitory pentapeptide (pepstatin) in the treatment of duodenal ulcer.
作者信息
Bonnevie O, Svendsen L B, Holst-Christensen J, Johansen T S, Søltoft J, Christiansen P M
出版信息
Gut. 1979 Jul;20(7):624-8. doi: 10.1136/gut.20.7.624.
Abstract
In a double-blind randomised clinical trial a specific inhibition of peptic activity with a pentapeptide, pepstatin, had no significant advantage over placebo in the ulcer healing and symptomatology of duodenal ulcer. Thus, the inhibition of pepsin in human gastric juice does not appear to have a major influence on the healing of duodenal ulcer.
摘要
在一项双盲随机临床试验中，用一种五肽胃蛋白酶抑制剂对消化活性进行特异性抑制，在十二指肠溃疡的愈合及症状方面，与安慰剂相比并无显著优势。因此，抑制人胃液中的胃蛋白酶似乎对十二指肠溃疡的愈合没有重大影响。
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本文引用的文献
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ANTACID THERAPY OF PEPTIC ULCER. II. AN EVALUATION OF ANTACIDS IN VITRO.消化性溃疡的抗酸治疗。II. 抗酸剂的体外评估
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Mechanism of the antipeptic action of amylopectin sulfate (SN-263), and antiulcer, mucin-like agent.硫酸支链淀粉（SN - 263）的抗消化作用机制，以及抗溃疡、类黏蛋白剂。
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