Svendsen L B, Guldager N, Christensen L, Christiansen P M
Scand J Gastroenterol. 1976;11(5):459-64.
The effect of a pepsin-inhibiting pentapeptide, pepstatin, upon the peptic activity and gastric acidity was investigated in 9 men with ulcer dyspepsia and a high acid output. Subtotal inhibition of peptic activity was obtained, basally as well as after broth stimulation, as early as 15 minutes after the method of administration, and the inhibition remained almost unchanged during the 60 minutes of the experimental period. The acidity was not affected by pepstatin. No side-effects occurred. The results confirm preliminary reports on the pepsin-inhibitory activity of the drug. It is concluded that pepstatin ought to be investigated with regard to its clinical effect upon peptic ulcer.
研究了一种抑制胃蛋白酶的五肽——胃抑素对9名患有溃疡型消化不良且胃酸分泌过多的男性的胃蛋白酶活性和胃酸度的影响。早在给药后15分钟，无论基础状态还是肉汤刺激后，胃蛋白酶活性均得到几乎完全抑制，且在60分钟的实验期内抑制作用几乎保持不变。胃酸度不受胃抑素影响。未出现副作用。这些结果证实了关于该药物胃蛋白酶抑制活性的初步报告。得出结论，胃抑素应对消化性溃疡的临床效果进行研究。
