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解析流感保护相关性：来自人类 A/H1N1 挑战的经验教训。

Unravelling influenza correlates of protection: lessons from human A/H1N1 Challenge.

机构信息

Department of Clinical Science, The Influenza Centre, University of Bergen, Bergen, Norway.

Department of Microbiology, Haukeland University Hopsital, Bergen, Norway.

出版信息

mBio. 2024 May 8;15(5):e0006424. doi: 10.1128/mbio.00064-24. Epub 2024 Mar 28.

DOI:10.1128/mbio.00064-24
PMID:38546212
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11078003/
Abstract

Mucosal immunity is important in protecting from upper respiratory tract influenza infection. Human challenge provides a unique model to define correlates of protection with baseline immune responses being correlated to the quantity and length of viral shedding and clinical outcomes. Here, we discuss recent work on mucosal and systemic correlates of protection (R. Bean, L. T. Giurgea, A. Han, L. Czajkowski, et al., mBio 15:e02372-23, 2024, https://doi.org/10.1128/mbio.02372-23) and place it in the context of previous work on mucosal immunity. We also discuss the importance of standardized assays to allow global comparison of relevant immune responses in defining correlates of protection. Correlates of protection are important for designing next-generation broadly protective influenza vaccines.

摘要

黏膜免疫对于预防上呼吸道流感感染非常重要。人类挑战模型为确定保护相关因素提供了一个独特的模型，基础免疫反应与病毒脱落的数量和时间以及临床结果相关。在这里，我们讨论了黏膜和系统保护相关因素的最新研究进展（R. Bean、L. T. Giurgea、A. Han、L. Czajkowski 等人，mBio 15:e02372-23, 2024, https://doi.org/10.1128/mBio.02372-23），并将其置于以前关于黏膜免疫的研究背景下进行讨论。我们还讨论了标准化检测方法的重要性，这对于在确定保护相关因素时，对相关免疫反应进行全球比较非常重要。保护相关因素对于设计新一代广泛保护性流感疫苗非常重要。