Department of Dermatology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.
Department of Dermatology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.
An Bras Dermatol. 2024 Jul-Aug;99(4):503-512. doi: 10.1016/j.abd.2023.09.004. Epub 2024 Mar 27.
The treatment for atopic dermatitis (AD) has been the focus of clinical research, and behavioral intervention is considered an indispensable treatment method. To our knowledge, no relevant meta-analysis has evaluated the effects of behavioral interventions on atopic dermatitis.
To evaluate the effects of behavioral interventions on atopic dermatitis.
The authors searched PubMed, EMBASE, and Cochrane CENTRAL to retrieve relevant RCTs (up to Feb 2022). The search strategy involved a combination of related keywords. The Cochrane Q and I statistics were used to assess heterogeneity.
Six RCTs involving seven reports with 246 patients were included. The results suggested that behavioral interventions could relieve eczema severity (correlation coefficient [r = -0.39]; p < 0.001) and scratching severity significantly (r = -0.19; p = 0.017), while not affect itching intensity (r = -0.02; p = 0.840). A sensitivity analysis confirmed the robustness of the results.
An important limitation of this study was the insufficient number of RCTs and the limited sample size. In addition, the study lacked a control group receiving a type of intervention other than the experimental protocol. Another limitation was the short duration of follow-up.
This study suggests that behavioral interventions could be effective in treating atopic dermatitis by reducing eczema and scratching severity. Additionally, habit-reversal behavioral therapy may be more effective for treating atopic dermatitis.
特应性皮炎（AD）的治疗一直是临床研究的重点，行为干预被认为是不可或缺的治疗方法。据我们所知，尚无相关的荟萃分析评估行为干预对特应性皮炎的影响。
评估行为干预对特应性皮炎的影响。
作者检索了 PubMed、EMBASE 和 Cochrane CENTRAL，以检索相关的 RCT（截至 2022 年 2 月）。搜索策略涉及相关关键字的组合。使用 Cochrane Q 和 I 统计量评估异质性。
纳入了 6 项 RCT，共涉及 7 项报告，共 246 名患者。结果表明，行为干预可以显著缓解湿疹严重程度（相关系数[r=-0.39]；p<0.001）和搔抓严重程度（r=-0.19；p=0.017），但对瘙痒强度无影响（r=-0.02；p=0.840）。敏感性分析证实了结果的稳健性。
本研究的一个重要局限性是 RCT 数量不足且样本量有限。此外，该研究缺乏接受实验方案以外的某种干预措施的对照组。另一个局限性是随访时间短。
本研究表明，行为干预通过降低湿疹和搔抓严重程度可能对特应性皮炎有效。此外，习惯反转行为疗法可能对特应性皮炎的治疗更有效。
