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重新构建黑人和拉丁裔人群特应性皮炎中的种族和民族差异。

Reframing racial and ethnic disparities in atopic dermatitis in Black and Latinx populations.

机构信息

The University of Texas at Austin, School of Nursing, Austin, Tex; Dell Children's Medical Group, Austin, Tex.

Dell Children's Medical Group, Austin, Tex; The University of Texas at Austin Dell Medical School, Austin, Tex.

出版信息

J Allergy Clin Immunol. 2021 Nov;148(5):1104-1111. doi: 10.1016/j.jaci.2021.09.015. Epub 2021 Sep 30.

Abstract

Black people in the United States experience greater atopic dermatitis (AD) prevalence, severity, and persistence when compared with White people. Although very little published literature describes AD in the Latinx population, additional differences in severity, persistence, and age of onset exist in contrast to White people. Thus far, genetic polymorphisms associated with increased risk and/or severity of AD are less common among Black people, so should confer reduced, rather than the observed increased, AD risk among Black people. Little is known regarding genetic risk factors in Latinx people. In contrast, there is consistent evidence that socioeconomic, environmental, and health care factors influence AD prevalence, severity, and/or persistence, and these same risk factors are more common among racial and ethnic minority populations as a result of racism. Researchers too often pursue genetic explanations for racial and ethnic AD disparities when the evidence points to the importance of contextual, rather than genetic, causes of these disparities. Reframing the prevailing view that innate differences among racial and ethnic groups are responsible for these disparities by emphasizing the role of racism and its downstream effects on contextual factors will be a critical first step toward shrinking these disparities.

摘要

与白人相比,美国黑人的特应性皮炎(AD)患病率、严重程度和持续性更高。尽管很少有文献描述拉丁裔人群中的 AD,但与白人相比,严重程度、持续性和发病年龄存在额外的差异。到目前为止,与 AD 风险增加和/或严重程度相关的遗传多态性在黑人中较为少见,因此在黑人中,AD 的风险应该降低,而不是观察到的增加。关于拉丁裔人群的遗传风险因素知之甚少。相比之下,有确凿证据表明,社会经济、环境和医疗保健因素会影响 AD 的患病率、严重程度和/或持续性,由于种族主义,这些相同的风险因素在种族和族裔少数群体中更为常见。研究人员经常在有证据表明这些差异的原因是上下文因素而非遗传因素的情况下,寻求遗传解释来解释种族和族裔 AD 差异。通过强调种族主义及其对上下文因素的下游影响在造成这些差异中的作用,重新定义一种普遍观点,即认为种族和族裔群体之间存在内在差异是造成这些差异的原因,这将是缩小这些差异的关键第一步。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e14/8578465/18ce4be02a2d/nihms-1742935-f0001.jpg

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