Vidas Pauk Sania, Petriček Igor, Jukić Tomislav, Popović-Suić Smiljka, Tomić Martina, Kalauz Miro, Jandroković Sonja, Masnec Sanja
1Department of Ophthalmology, Zagreb University Hospital Centre, Zagreb, Croatia; 2Vuk Vrhovac University Clinic for Diabetes, Endocrinology and Metabolic Diseases, Merkur University Hospital, Zagreb, Croatia.
Acta Clin Croat. 2019 Mar;58(1):63-71. doi: 10.20471/acc.2019.58.01.09.
The aim was to determine feasibility and reliability of noninvasive tear break-up time (NIBUT) assessment using handheld lipid layer examination instrument, and to compare it with standard tear break-up time (TBUT) test. Fifty patients were enrolled, 31 with and 19 without dry eye symptoms. Schein questionnaire was used to assess dry eye symptoms. During examination, three NIBUT measurements were performed on each eye using handheld instrument, followed by three TBUT measurements. Receiver operating characteristic curves, sensitivity, specificity and logistic regression analysis were generated. Median NIBUT values were significantly shorter in dry eye symptom group than in control group in all three measurements (9, 8 and 8 s . 21, 22 and 21 s; p<0.001). TBUT values showed no significant difference between the groups in the first measurement (p=0.053), but the values were significantly shorter in dry eye symptom group in second and third measurements (p=0.020). The cutoff value to distinguish patients with symptoms of dry eye from control group was 12 seconds for NIBUT and 8 seconds for TBUT, with NIBUT having significantly higher sensitivity, specificity, area under the receiver operating characteristic curve and positive predictive value. NIBUT, measured by handheld lipid layer examination instrument, was superior to TBUT in detecting dry eye.
目的是确定使用手持式脂质层检查仪器评估无创泪膜破裂时间（NIBUT）的可行性和可靠性，并将其与标准泪膜破裂时间（TBUT）测试进行比较。招募了50名患者，其中31名有干眼症状，19名没有干眼症状。使用Schein问卷评估干眼症状。检查期间，使用手持式仪器对每只眼睛进行三次NIBUT测量，然后进行三次TBUT测量。生成了受试者工作特征曲线、敏感性、特异性和逻辑回归分析。在所有三次测量中，干眼症状组的NIBUT中位数均显著短于对照组（9、8和8秒对21、22和21秒；p<0.001）。TBUT值在第一次测量中两组之间无显著差异（p=0.053），但在第二次和第三次测量中，干眼症状组的值显著较短（p=0.020）。区分有干眼症状患者与对照组的临界值，NIBUT为12秒，TBUT为8秒，NIBUT的敏感性、特异性、受试者工作特征曲线下面积和阳性预测值显著更高。通过手持式脂质层检查仪器测量的NIBUT在检测干眼中优于TBUT。
