Alanazi Saud A, Alomran Abdullah A, Abusharha Ali, Fagehi Raied, Al-Johani Naji J, El-Hiti Gamal A, Masmali Ali M
Cornea Research Chair, Department of Optometry, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia.
Comprehensive Cancer Center, Department of Endocrinology and Thyroid Oncology, King Fahad Medical City, Riyadh, Saudi Arabia.
Clin Ophthalmol. 2019 Jun 28;13:1019-1026. doi: 10.2147/OPTH.S210044. eCollection 2019.
To investigate the ocular tear film in patients with thyroid disorders using various tests. The study involved the assessment of the ocular tear film in 20 patients with thyroid disorders (6 men and 14 women) aged 18-43 years (mean±standard deviation=34.3±3.2 years). An age-matched control group consisting of 20 subjects (8 males and 12 females) ranging in age from 18 to 43 years (31.3±2.9 years) was also examined under similar conditions. All patients completed the Ocular Surface Disease Index questionnaire, followed by the tear ferning test within the right eye. A phenol red thread test was carried out 10 mins later followed by the fluorescein tear break-up test with a 10-min gap between the tests being implemented. The median score for the Ocular Surface Disease Index (<0.05) showed the condition of mild dry eyes [median (IQR)=15.5 (21.9)] in patients with thyroid disorders compared to the control group [5.6 (3.6)]. The mean score for the phenol red thread test within both the right and left eyes showed acceptable tear volumes of 11.7±8.1 and 10.5±7.4 mm, respectively, but this was much lower (<0.05) compared to those recorded within the control group (22.2±6.5 and 20.7±5.2 mm, respectively). In addition, the mean for the tear break-up time (<0.05) scores in both eyes within the patients with thyroid disorders revealed a certain degree of eye dryness (4.9±1.6 and 4.2±1.9 s), while the control group showed normal eye scores (13.2±2.6 and 12.3±2.2 s). The median score for tear ferning grades showed eye dryness [2.0 (2.2)] within the study group and normal eyes [1.2 (0.9)] within the control group. Patients with thyroid disorders have a significant level of eye dryness compared to normal eye subjects.
使用各种测试方法研究甲状腺疾病患者的眼表泪膜。该研究对20例年龄在18 - 43岁（平均±标准差 = 34.3±3.2岁）的甲状腺疾病患者（6名男性和14名女性）的眼表泪膜进行了评估。还在相似条件下检查了一个年龄匹配的对照组，该组由20名年龄在18至43岁（31.3±2.9岁）的受试者（8名男性和12名女性）组成。所有患者均完成眼表疾病指数问卷，随后对右眼进行泪液蕨类结晶试验。10分钟后进行酚红棉线试验，之后进行荧光素泪膜破裂试验，两次试验间隔10分钟。与对照组[5.6（3.6）]相比，甲状腺疾病患者的眼表疾病指数中位数得分（<0.05）显示存在轻度干眼状况[中位数（四分位间距）= 15.5（21.9）]。右眼和左眼酚红棉线试验的平均得分分别显示泪液量可接受，为11.7±8.1和10.5±7.4毫米，但与对照组记录的数值（分别为22.2±6.5和20.7±5.2毫米）相比要低得多（<0.05）。此外，甲状腺疾病患者双眼泪膜破裂时间的平均得分（<0.05）显示存在一定程度的干眼（4.9±1.6和4.2±1.9秒），而对照组显示眼表得分正常（13.2±2.6和12.3±2.2秒）。泪液蕨类结晶等级的中位数得分显示研究组存在干眼[2.0（2.2）]，对照组眼表正常[1.2（0.9）]。与正常眼受试者相比，甲状腺疾病患者的干眼程度明显更高。
