Locasciulli A, Santamaria M, Masera G, Schiavon E, Alberti A, Realdi G
J Med Virol. 1985 Jan;15(1):29-33. doi: 10.1002/jmv.1890150105.
Hepatitis B virus markers were tested in the serum of 49 children with acute leukemia on clinical presentation and during subsequent chemotherapy. Hepatitis B surface antigenemia was observed in only six patients (12%), none of whom progressed to chronic infection. Chemotherapy had a marked suppressive effect on the production of antibodies to hepatitis B virus antigens and overt infection occurred in two children after suppression of protective immunity. Evidence of liver damage was frequently observed and was largely independent of serologic data. These results indicate that active immunization with hepatitis B vaccine may not find a clear place in this clinical setting.
对49例急性白血病患儿在临床表现期及随后化疗期间的血清进行了乙肝病毒标志物检测。仅6例患者（12%）出现乙肝表面抗原血症，其中无一例进展为慢性感染。化疗对乙肝病毒抗原抗体的产生有显著抑制作用，在保护性免疫受到抑制后，两名儿童发生了显性感染。经常观察到肝损伤迹象，且在很大程度上与血清学数据无关。这些结果表明，在这种临床情况下，乙肝疫苗主动免疫可能没有明确的应用价值。
