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照亮道路:分子光遗传学的最新进展和应用。

Lighting the way: recent developments and applications in molecular optogenetics.

机构信息

INM - Leibniz Institute for New Materials, Campus D2 2, 66123 Saarbrücken, Germany; CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, Schänzlestr. 18, 79104 Freiburg, Germany; Faculty of Biology, University of Freiburg, Schänzlestr. 1, 79104 Freiburg, Germany.

INM - Leibniz Institute for New Materials, Campus D2 2, 66123 Saarbrücken, Germany.

出版信息

Curr Opin Biotechnol. 2024 Jun;87:103126. doi: 10.1016/j.copbio.2024.103126. Epub 2024 Mar 29.

Abstract

Molecular optogenetics utilizes genetically encoded, light-responsive protein switches to control the function of molecular processes. Over the last two years, there have been notable advances in the development of novel optogenetic switches, their utilization in elucidating intricate signaling pathways, and their progress toward practical applications in biotechnological processes, material sciences, and therapeutic applications. In this review, we discuss these areas, offer insights into recent developments, and contemplate future directions.

摘要

分子光遗传学利用基因编码的、对光有响应的蛋白质开关来控制分子过程的功能。在过去的两年中,新型光遗传学开关的开发、它们在阐明复杂信号通路方面的应用以及它们在生物技术过程、材料科学和治疗应用中的实际应用方面都取得了显著的进展。在这篇综述中,我们讨论了这些领域,提供了对最新发展的见解,并思考了未来的方向。

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