Recep Tayyip Erdoğan University, Department of Oral and Maxillofacial Surgery, Rize, Türkiye.
Recep Tayyip Erdoğan University, Department of Histology and Embrylogy, Rize, Türkiye.
J Stomatol Oral Maxillofac Surg. 2024 Oct;125(5S2):101850. doi: 10.1016/j.jormas.2024.101850. Epub 2024 Mar 28.
Mandibular nerve injury is a common clinical condition that affects clinicians' management and patients' quality of life. In the literature, there are various effective treatments available. The primary purpose of this study was to determine and compare the effects of dexamethasone and concentrated growth factor (CGF) on regeneration in patients with nerve trauma that mimics clinical situations.
In this study, 36 rats were divided into 3 groups: the control, dexamethasone and CGF groups. The inferior alveolar nerve was traumatized through the extraction socket after mandibular molar tooth extraction in each group.
The data showed a decrease in the control (4.5-4), dexamethasone (3-2), and CGF (4-3) groups according to the histological injury severity score (HISS) results. Compared with those in the other groups, the number of degenerative axons and edematous areas observed via histological examination were significantly lower in the CGF groups. Similarly, compared with those in the control group, the nNOS and Neurofilament-H positivity in the dexamethasone group on the 30th day (2,2 to 1,1 respectively) was significantly lower. The positivity of all the primary antibodies in the 3rd and 30th day CGF groups was significant compared than that in the dexamethasone 30th day group.
According to the results of the analysis of the immunohistopathological and HISS data, the CGF groups exhibited greater regeneration than did the dexamethasone groups.
下颌神经损伤是一种常见的临床情况，会影响临床医生的治疗决策和患者的生活质量。目前有多种有效的治疗方法。本研究的主要目的是确定和比较地塞米松和浓缩生长因子（CGF）对模拟临床情况的神经损伤患者再生的影响。
本研究将 36 只大鼠分为 3 组：对照组、地塞米松组和 CGF 组。每组通过下颌磨牙拔除后的拔牙窝创伤下颌下神经。
根据组织损伤严重程度评分（HISS）结果，对照组（4.5-4）、地塞米松组（3-2）和 CGF 组（4-3）的数值均下降。与其他组相比，CGF 组的组织学检查显示退行性轴突和水肿区数量明显减少。同样，与对照组相比，地塞米松组第 30 天的 nNOS 和神经丝蛋白-H 阳性率（分别为 2,2 至 1,1）显著降低。与地塞米松组第 30 天相比，CGF 组第 3 天和第 30 天所有主要抗体的阳性率均显著升高。
根据免疫组织病理学和 HISS 数据分析的结果，CGF 组的再生效果优于地塞米松组。
